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author：

Liu, W. (Liu, W..) [1] | Ye, J. (Ye, J..) [2] | Wang, Y. (Wang, Y..) [3] | Xu, X. (Xu, X..) [4] | Gao, Y. (Gao, Y..) [5] | Liu, K. (Liu, K..) [6] | Gao, J. (Gao, J..) [7] | Lin, Y. (Lin, Y..) [8] | Cui, L. (Cui, L..) [9] | Wu, Q. (Wu, Q..) [10] | Yang, H. (Yang, H..) [11] | Zhang, J. (Zhang, J..) [12]

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Scopus

Abstract：

Healing　of　chronic　wounds　becomes　a　global　health　issue　due　to　increasing　incidence　and　associated　burdens,　and　therefore　promoting　tissue-remodeling　and　monitoring　wound-status　visually　are　of　particular　significance.　Herein,　an　electronic-skin　patch　(TENG-gel)　composed　by　polydimethylsiloxane/polytetrafluoroethylene　film,　eutectic　gallium–indium　(E-GaIn),　and　quaternary　chitosan/polyacrylamide/sodium　alginate@molybdenum　disulfide　(MoS2)　nanosheet　(HQPS@MoS2)　composite　hydrogel　is　assembled　layer-by-layer.　First,　the　TENG-gel　realizes　multimodal　antibacterial　by　integrating　peroxidase-like　activity,　photothermal　therapy,　and　nano-knife　effect,　which　eliminates　both　Gram-positive/negative　bacteria　with　killing　ratio　of　above　95%.　Besides,　electrical　stimulation　generated　from　the　TENG-gel　promotes　migration　of　fibroblasts　after　an　incubation　of　48 h　by　activating　signaling　pathways,　and　meanwhile　accelerates　vascularization　by　secreting　different　growth　factors　of　CD31,　VEGF,　and　TGF-β.　Through　providing　an　ideal　microenvironment　for　tissue　repair,　the　TENG-gel　achieves　1.6-fold　new　hair　follicles　and　2.4-fold　collagen　deposition　compared with　those　of　the　control　group.　More　interestingly,　dual　temperature-/strain-sensing　performance　enables　the　TENG-gel　with　capability　of　monitoring　wound　status　or　reminding　external　danger　signals　in　real-time　dependent　on　variational　electrical　signals.　Overall,　unique　advantages　of　such　smart　electronic-skin　patch　provide　a　personalized　medicine　strategy　for　realizing　tissue　reconstruction　and　monitoring　synchronously.　©　2025　Wiley-VCH　GmbH.

Keyword：

chronic wounds MoS2 nanosheets multimodal antibacterial real-time monitoring wireless self-powered

Community：

  • [ 1 ] [Liu W.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, 2 Xueyuan Road, Fuzhou, 350108, China
  • [ 2 ] [Liu W.]Qingyuan Innovation Laboratory, 1 Xueyuan Road, Quanzhou, 362801, China
  • [ 3 ] [Ye J.]Department of Trauma Center and Emergency Surgery, The First Affiliated Hospital of Fujian Medical University, 20 Chazhong Road, Fuzhou, 350005, China
  • [ 4 ] [Ye J.]Department of Trauma Center and Emergency Surgery, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, 999 Huashan Road, Fuzhou, 350200, China
  • [ 5 ] [Wang Y.]School of Advanced Manufacturing, Fuzhou University, 1 Shuicheng Road, Jinjiang, 362200, China
  • [ 6 ] [Xu X.]College of Biological Science and Engineering, Fuzhou University, 2 Xueyuan Road, Fuzhou, 350108, China
  • [ 7 ] [Gao Y.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, 2 Xueyuan Road, Fuzhou, 350108, China
  • [ 8 ] [Gao Y.]Qingyuan Innovation Laboratory, 1 Xueyuan Road, Quanzhou, 362801, China
  • [ 9 ] [Liu K.]Qingyuan Innovation Laboratory, 1 Xueyuan Road, Quanzhou, 362801, China
  • [ 10 ] [Liu K.]College of Chemical Engineering, Fuzhou University, 2 Xueyuan Road, Fuzhou, 350108, China
  • [ 11 ] [Gao J.]School of Chemistry and Chemical Engineering, Yangzhou University, 180 Siwangting Road, Yangzhou, 225002, China
  • [ 12 ] [Lin Y.]Qingyuan Innovation Laboratory, 1 Xueyuan Road, Quanzhou, 362801, China
  • [ 13 ] [Lin Y.]College of Chemical Engineering, Fuzhou University, 2 Xueyuan Road, Fuzhou, 350108, China
  • [ 14 ] [Cui L.]Qingyuan Innovation Laboratory, 1 Xueyuan Road, Quanzhou, 362801, China
  • [ 15 ] [Cui L.]College of Chemical Engineering, Fuzhou University, 2 Xueyuan Road, Fuzhou, 350108, China
  • [ 16 ] [Wu Q.]Department of Trauma Center and Emergency Surgery, The First Affiliated Hospital of Fujian Medical University, 20 Chazhong Road, Fuzhou, 350005, China
  • [ 17 ] [Wu Q.]Department of Trauma Center and Emergency Surgery, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, 999 Huashan Road, Fuzhou, 350200, China
  • [ 18 ] [Yang H.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, 2 Xueyuan Road, Fuzhou, 350108, China
  • [ 19 ] [Yang H.]Qingyuan Innovation Laboratory, 1 Xueyuan Road, Quanzhou, 362801, China
  • [ 20 ] [Zhang J.]Qingyuan Innovation Laboratory, 1 Xueyuan Road, Quanzhou, 362801, China
  • [ 21 ] [Zhang J.]College of Chemical Engineering, Fuzhou University, 2 Xueyuan Road, Fuzhou, 350108, China

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Advanced Functional Materials

ISSN： 1616-301X

Year： 2025

1 8 . 5 0 0

JCR@2023

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ESI Highly Cited Papers on the List： 0 Unfold All

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30 Days PV： 1

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