Objectives:　The　effectiveness　of　low-load　blood　flow　restriction　training　(LL-BFRT)　in　alleviating　symptoms　in　patients　with　knee　osteoarthritis　(KOA)　remains　inconclusive.　This　systematic　review　and　meta-analysis　aim　to　comprehensively　assess　the　effects　of　LL-BFRT　compared　to　conventional　resistance　training　on　pain,　muscle　strength,　and　functional　capacity　in　individuals　with　KOA.　Data　sources:　PubMed,　Embase,　Web　of　Science,　EBSCO,　Scopus,　and　Cochrane　trails　were　searched.　Study　selection:　We　included　randomized　controlled　trials　involving　patients　with　KOA,　in　which　the　intervention　group　underwent　LL-BFRT.　Data　extraction　Literature　quality　and　risk　of　bias　were　assessed　using　the　Physiotherapy　Evidence　Database　(PEDro)　scale　and　the　Cochrane　Risk-of-Bias　Tool　(ROB　2).　Data　were　extracted　using　a　predefined　table,　including　outcomes　such　as　pain,　quadriceps　muscle　strength,　30-s　sit-to-stand　test　(30STS)　and　Timed　Up　and　Go　test　(TUG).　Result:　Ten　studies　were　included　in　the　meta-analysis.　The　pooled　results　indicated　that,　compared　to　conventional　resistance　training,　LL-BFRT　significantly　improved　knee　joint　pain　[SMD　=　0.25,　95%CI　(0.02,　0.48),　P　=　0.03],　increased　quadriceps　muscle　strength　[SMD　=　0.46,　95%CI　(0.04,　0.88),　P　=　0.03],　and　enhanced　performance　on　the　30s　sit-to-stand　test　(30STS)　[WMD　=　1.71,　95%CI　(0.30,　3.11),　P　=　0.02].　However,　no　significant　difference　was　observed　in　the　improvement　of　the　Timed　Up　and　Go　test　(TUG)　[WMD　=　-0.13,　95%CI　(-0.51,　0.24),　P　=　0.49].　Subgroup　analysis　revealed　that　interventions　with　an　occlusion　pressure　＞100　mmHg　and　a　duration　＜=　6　weeks　had　a　significant　impact　on　pain　relief,　quadriceps　muscle　strength,　and　the　30STS　performance.　For　patients　with　KOA　aged　＞65　years,　LL-BFRT　was　more　effective　in　alleviating　pain,　while　for　patients　aged　＜=　65　years,　it　demonstrated　more　significant　improvements　in　quadriceps　strength　and　30STS　performance.　Conclusion:　Limited　evidence　suggests　that　LL-BFRT　may　be　more　effective　than　conventional　resistance　training　in　improving　pain,　quadriceps　muscle　strength,　and　30STS　performance　in　patients　with　KOA,　while　exhibiting　a　comparable　effect　on　TUG　test.