Objective:　With　the　intention　of　developing　a　more　targeted　control　strategy　for　retinal　vein　occlusion　(RVO)　in　East　Asian　populations,　a　meta-analysis　was　conducted　to　evaluate　the　risk　factors　associated　with　RVO　in　this　region.　Methods:　PubMed,　Web　of　Science,　Cochrane　Library,　CNKI,　Wanfang　and　VIP　databases　were　searched　for　studies　that　reported　risk　factors　of　RVO　in　East　Asia,　published　from　the　establishment　of　the　database　to　May　2024.　To　further　filter　the　articles,　Newcastle-Ottawa　Scale　(NOS)　evaluation　method　was　utilized　to　assess　the　quality　of　selected　articles.　After　valid　data　were　extracted,　Meta-analysis　was　performed　by　Review　Manager　software.　Results:　A　total　of　21　literatures　were　included,　including　27561　cases　in　the　RVO　group　(Case　group)　and　514578　cases　in　the　non-retinal　vein　occlusion　(NRVO)　group　(Control　group).　Results　of　meta-analysis　showed　that　chronic　kidney　disease　[odds　ratio　(OR)=4.14,　95%　confidence　interval　(CI):　(1.86%,　9.24%)],　hypertension　[OR=4.11,　95%　CI:　(3.09%,　5.48%)],　hyperlipidemia　[OR=3.45,　95%CI:　(2.32%,　5.12%)],　diabetes　mellitus　[OR=3.00,　95%CI:　(1.88%,　4.80%)],　homocysteine　[OR=0.87,　95%CI:　(0.59%,　1.15%)],　have　statistically　significant　differences　between　the　RVO　group　and　the　NRVO　group(P＜0.05).　Conclusion:　The　occurrence　of　RVO　is　closely　related　to　its　risk　factors,　such　as　chronic　kidney　disease,　hypertension,　hyperlipidemia,　diabetes　mellitus　and　high　homocysteine.　In　the　process　of　diagnosis　and　treatment　of　RVO,　doctors　should　focus　on　the　above　risk　factors　to　prevent　the　occurrence　of　the　disease.　Copyright　©　2025　Qiu,　Jiao,　Liu,　Zhou,　Li,　Chen　and　Liu.