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author:

Li, Huamin (Li, Huamin.) [1] | Zhang, Ying (Zhang, Ying.) [2] | Wu, Haidi (Wu, Haidi.) [3] | Liu, Zhanqi (Liu, Zhanqi.) [4] | Guan, Cheng (Guan, Cheng.) [5] | Zhang, Jin (Zhang, Jin.) [6] | Chen, Jingyi (Chen, Jingyi.) [7] | He, Shaohua (He, Shaohua.) [8] | Huang, Xuewu (Huang, Xuewu.) [9] | Gu, Wancheng (Gu, Wancheng.) [10] | Mai, Yiu Wing (Mai, Yiu Wing.) [11] | Gao, Jiefeng (Gao, Jiefeng.) [12]

Indexed by:

SCIE

Abstract:

It is highly desirable but still remains challenging to develop high-performance hydrogels with satisfactory mechanical properties for tissue engineering. Here, anisotropic yet transparent hydrogels (AHs) are prepared for tendon repair via a facile "poor solvent evaporation assisted hot-stretching" strategy. AHs have great mechanical properties with tensile strength, toughness, and fracture energy as high as 33.14 +/- 2.05 MPa, 44.1 +/- 3.5 MJ m(-3), and 106.18 +/- 7.2 kJ m(-2), respectively. Especially, AHs show unique flaw-insensitive characteristics, and cracks can only deflect along the fiber alignment direction rather than propagate transverse to this direction, showing an interesting self-protection function. The high strength, toughness, and fatigue resistance originate from the hierarchal structure of AHs, i.e., the densified polymeric network comprising fiber bundles and nanofibrils with aligned macromolecular chains, crystalline domains, and intermolecular hydrogen bonds. AHs with superior biocompatibility and swelling resistance can be used to repair rat tendons, and implantation of AHs can promote collagen regeneration for the tendon repair. This study provides a new method to fabricate strong and anti-fatigue hydrogels as a new class of promising materials for soft tissues.

Keyword:

anisotropic hydrogels flaw-insensitivity hot-stretching poor solvent evaporation tendon repair

Community:

  • [ 1 ] [Li, Huamin]Yangzhou Univ, Sch Chem & Chem Engn, 180 Rd Siwangting, Yangzhou 225002, Jiangsu, Peoples R China
  • [ 2 ] [Wu, Haidi]Yangzhou Univ, Sch Chem & Chem Engn, 180 Rd Siwangting, Yangzhou 225002, Jiangsu, Peoples R China
  • [ 3 ] [Liu, Zhanqi]Yangzhou Univ, Sch Chem & Chem Engn, 180 Rd Siwangting, Yangzhou 225002, Jiangsu, Peoples R China
  • [ 4 ] [Guan, Cheng]Yangzhou Univ, Sch Chem & Chem Engn, 180 Rd Siwangting, Yangzhou 225002, Jiangsu, Peoples R China
  • [ 5 ] [Huang, Xuewu]Yangzhou Univ, Sch Chem & Chem Engn, 180 Rd Siwangting, Yangzhou 225002, Jiangsu, Peoples R China
  • [ 6 ] [Gu, Wancheng]Yangzhou Univ, Sch Chem & Chem Engn, 180 Rd Siwangting, Yangzhou 225002, Jiangsu, Peoples R China
  • [ 7 ] [Gao, Jiefeng]Yangzhou Univ, Sch Chem & Chem Engn, 180 Rd Siwangting, Yangzhou 225002, Jiangsu, Peoples R China
  • [ 8 ] [Zhang, Ying]Fuzhou Univ, Coll Chem, MOE Key Lab Analyt Sci Food Safety & Biol, 2 Xueyuan Rd, Fuzhou 350108, Peoples R China
  • [ 9 ] [Zhang, Jin]Fuzhou Univ, Coll Chem Engn, 2 Xueyuan Rd, Fuzhou 350108, Peoples R China
  • [ 10 ] [Zhang, Jin]Qingyuan Innovat Lab, 1 Xueyuan Rd, Quanzhou 362801, Peoples R China
  • [ 11 ] [Chen, Jingyi]Fuzhou Univ, Affiliated Prov Hosp, 134 Dongjie Rd, Fuzhou 350001, Fujian, Peoples R China
  • [ 12 ] [He, Shaohua]Fuzhou Univ, Affiliated Prov Hosp, 134 Dongjie Rd, Fuzhou 350001, Fujian, Peoples R China
  • [ 13 ] [Mai, Yiu Wing]Hong Kong Polytech Univ, Dept Mech Engn, Hung Hom, Kowloon, Hong Kong 999077, Peoples R China

Reprint 's Address:

  • [Gao, Jiefeng]Yangzhou Univ, Sch Chem & Chem Engn, 180 Rd Siwangting, Yangzhou 225002, Jiangsu, Peoples R China;;[Zhang, Jin]Fuzhou Univ, Coll Chem Engn, 2 Xueyuan Rd, Fuzhou 350108, Peoples R China;;[Zhang, Jin]Qingyuan Innovat Lab, 1 Xueyuan Rd, Quanzhou 362801, Peoples R China

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ADVANCED SCIENCE

Year: 2025

1 4 . 3 0 0

JCR@2023

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ESI Highly Cited Papers on the List: 0 Unfold All

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30 Days PV: 0

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