PtSn　bimetallic　catalysts　applied　in　propane　dehydrogenation　(PDH)　reaction　suffer　from　deactivation　at　high　temperatures　(500-700　degrees　C)　due　to　metal　segregation　and　Sn-rich　cluster　formation.　This　study　demonstrates　that　supporting　PtSn　catalysts　on　Silicalite-1　zeolite　(S-1)　enhances　Sn　dispersion　through　interactions　with　silanol　hydroxyl　groups,　enabling　effective　regeneration　of　Pt-rich　PtSn　clusters　even　after　15　reaction-regeneration　cycles.　Comprehensive　characterizations　reveal　that　silanol　nests　play　a　critical　role　in　redispersing　metal　species　during　regeneration,　minimizing　aggregation,　and　maintaining　catalytic　activity.　The　enhanced　metalsupport　interactions　significantly　improve　catalyst　regenerability　and　stability,　addressing　key　challenges　in　industrial　PDH　processes.　This　work　highlights　the　importance　of　Sn　dispersion　and　metal-support　interactions　in　designing　durable　and　efficient　PtSn　catalysts,　offering　practical　insights　for　sustainable　propylene　production.