Psoriasis　is　a　prevalent　chronic　inflammatory　disorder　affecting　approximately　0.72%　of　the　Chinese　population.　Currently,　available　treatments　cannot　completely　cure　this　disease.　The　excessive　production　of　reactive　oxygen　species　(ROS)　has　been　considered　to　be　a　key　contributor　to　the　progression　of　psoriasis.　In　this　study,　Ce　and　Mn　were　doped　into　mesoporous　silicon　nanomaterials　with　optimized　ratios　that　could　form　uniform　and　well-dispersed　CM@MSNs　particles,　which　were　able　to　effectively　remove　a　wide　range　of　ROS.　As　a　result,　treatment　with　CM@MSNs　could　reduce　epidermal　hyperplasia　and　prevent　inflammatory　reactions　in　the　imiquimod　(IMQ)-induced　psoriasis-like　model　in　mice.　Mechanistically,　CM@MSNs　might　prevent　the　inflammation　by　repressing　the　IL-17　and　NF-kappa　B　signaling　pathways　and　ameliorating　epidermal　hyperplasia　through　the　activation　of　both　canonical　and　noncanonical　Wnt　signaling　pathways.　In　conclusion,　this　research　could　lead　to　a　promising　treatment　method　for　psoriasis.　This　work　provides　an　example　of　nanoenzymes　for　effectively　scavenging　ROS　of　diseases.