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author：

Sun, H. (Sun, H..) [1] | Yuan, H. (Yuan, H..) [2] | Hu, J. (Hu, J..) [3] | Chen, J. (Chen, J..) [4] | Han, J. (Han, J..) [5] | Wang, P. (Wang, P..) [6] | Lu, C.-Z. (Lu, C.-Z..) [7] | Hu, T. (Hu, T..) [8] | Li, Y. (Li, Y..) [9]

Indexed by：

Scopus

Abstract：

Psoriasis　is　a　prevalent　chronic　inflammatory　disorder　affecting　approximately　0.72%　of　the　Chinese　population.　Currently,　available　treatments　cannot　completely　cure　this　disease.　The　excessive　production　of　reactive　oxygen　species　(ROS)　has　been　considered　to　be　a　key　contributor　to　the　progression　of　psoriasis.　In　this　study,　Ce　and　Mn　were　doped　into　mesoporous　silicon　nanomaterials　with　optimized　ratios　that　could　form　uniform　and　well-dispersed　CM@MSNs　particles,　which　were　able　to　effectively　remove　a　wide　range　of　ROS.　As　a　result,　treatment　with　CM@MSNs　could　reduce　epidermal　hyperplasia　and　prevent　inflammatory　reactions　in　the　imiquimod　(IMQ)-induced　psoriasis-like　model　in　mice.　Mechanistically,　CM@MSNs　might　prevent　the　inflammation　by　repressing　the　IL-17　and　NF-κB　signaling　pathways　and　ameliorating　epidermal　hyperplasia　through　the　activation　of　both　canonical　and　noncanonical　Wnt　signaling　pathways.　In　conclusion,　this　research　could　lead　to　a　promising　treatment　method　for　psoriasis.　This　work　provides　an　example　of　nanoenzymes　for　effectively　scavenging　ROS　of　diseases.　©　2025　American　Chemical　Society.

Keyword：

antioxidant Ce−Mn-co-doped nanomaterials nanoenzymes psoriasis reactive oxygen species scavenging

Community：

  • [ 1 ] [Sun H.]State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, 350002, China
  • [ 2 ] [Sun H.]College of Chemistry, Fuzhou University, Fuzhou, 350116, China
  • [ 3 ] [Sun H.]Xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials, Xiamen Institute of Rare Earth Materials, Chinese Academy of Sciences, Xiamen, 361021, China
  • [ 4 ] [Sun H.]Fujian College, University of Chinese Academy of Sciences, Fuzhou, 350002, China
  • [ 5 ] [Yuan H.]State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, 350002, China
  • [ 6 ] [Yuan H.]Xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials, Xiamen Institute of Rare Earth Materials, Chinese Academy of Sciences, Xiamen, 361021, China
  • [ 7 ] [Yuan H.]Fujian College, University of Chinese Academy of Sciences, Fuzhou, 350002, China
  • [ 8 ] [Hu J.]State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, 350002, China
  • [ 9 ] [Hu J.]Xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials, Xiamen Institute of Rare Earth Materials, Chinese Academy of Sciences, Xiamen, 361021, China
  • [ 10 ] [Hu J.]Fujian College, University of Chinese Academy of Sciences, Fuzhou, 350002, China
  • [ 11 ] [Chen J.]School of Science and Technology, Hong Kong Metropolitan University, Hong Kong, B0711, Hong Kong
  • [ 12 ] [Han J.]School of Science and Technology, Hong Kong Metropolitan University, Hong Kong, B0711, Hong Kong
  • [ 13 ] [Wang P.]State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, 350002, China
  • [ 14 ] [Wang P.]Xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials, Xiamen Institute of Rare Earth Materials, Chinese Academy of Sciences, Xiamen, 361021, China
  • [ 15 ] [Wang P.]Fujian College, University of Chinese Academy of Sciences, Fuzhou, 350002, China
  • [ 16 ] [Lu C.-Z.]State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, 350002, China
  • [ 17 ] [Lu C.-Z.]Xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials, Xiamen Institute of Rare Earth Materials, Chinese Academy of Sciences, Xiamen, 361021, China
  • [ 18 ] [Lu C.-Z.]Fujian College, University of Chinese Academy of Sciences, Fuzhou, 350002, China
  • [ 19 ] [Hu T.]State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, 350002, China
  • [ 20 ] [Hu T.]Xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials, Xiamen Institute of Rare Earth Materials, Chinese Academy of Sciences, Xiamen, 361021, China
  • [ 21 ] [Hu T.]Fujian College, University of Chinese Academy of Sciences, Fuzhou, 350002, China
  • [ 22 ] [Li Y.]State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, 350002, China
  • [ 23 ] [Li Y.]Xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials, Xiamen Institute of Rare Earth Materials, Chinese Academy of Sciences, Xiamen, 361021, China
  • [ 24 ] [Li Y.]Fujian College, University of Chinese Academy of Sciences, Fuzhou, 350002, China

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Source ：

ACS Applied Nano Materials

ISSN： 2574-0970

Year： 2025

Issue： 22

Volume： 8

Page： 11415-11426

5 . 3 0 0

JCR@2023

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ESI Highly Cited Papers on the List： 0 Unfold All

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30 Days PV： 3

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