Metal-organic　frameworks　(MOFs)　based　on　nanomaterials　have　attracted　attention　for　tumor　microenvironment　(TME)-responsive　therapy.　However,　they　lack　intrinsic　imaging　capabilities　to　monitor　drug　release　and　predict　therapeutic　outcomes.　Herein,　metal-phenolic　nanosheets　(Cu/EA-MOF)　with　photoacoustic　(PA)　imaging　property　in　the　second　near-infrared　window　were　constructed　to　achieve　diagnosis　and　treatment　for　H2S-enriched　tumors.　Endogenous　H2S　triggers　the　decomposition　of　Cu/EA-MOF　into　the　ellagic　acid　(EA)　and　copper　sulfide　(Cu2-xS),　which　can　be　used　for　chemotherapy　and　chemodynamic　therapy,　respectively.　Moreover,　EA　can　enhance　the　efficiency　of　chemodynamic　therapy　by　boosting　superoxide　dismutase　activity.　Importantly,　the　degradation　of　Cu/EA-MOF　can　be　indicated　via　the　change　of　ratiometric　PA　signal　intensity.　Furthermore,　the　NIR-II　fluorescent　molecule　benzobisthiadiazole　(BBT)　was　further　introduced　into　Cu/EA-MOF　to　investigate　the　degradation　process　and　drug　release.　As　a　promising　theranostic　nanomaterial,　Cu/EA/BBT-MOF　is　successfully　used　to　achieve　effective　synergistic　therapy　and　predict　therapeutic　outcomes.　©　2025　The　Author(s)