Cancer　cachexia,　a　debilitating　syndrome　characterized　by　muscle　wasting　and　systemic　inflammation,　remains　a　major　unmet　clinical　need.　Qingxie　Fuzheng　Granules　(QFG),　a　traditional　Chinese　medicine　formulation,　have　shown　promise　in　cancer　therapy,　but　their　role　in　cachexia　management　is　unclear.Here,　we　investigated　the　anti-cachectic　effects　of　QFG　in　a　murine　model　of　colon　adenocarcinoma-induced　cachexia.　16S　rRNA　sequencing　revealed　gut　dysbiosis　in　cachectic　mice,　with　increased　Enterobacteriaceae　and　decreased　Lactobacillus.　QFG　treatment　restored　microbial　balance,　reduced　pro-inflammatory　cytokines　TNF-alpha,　IL-6,　and　enhanced　intestinal　barrier　integrity　by　upregulating　tight　junction　proteins　ZO-1,　Occludin,　Calprotectin.Mechanistically,　QFG　rebalanced　Th17/Treg　cell　ratios　and　suppressed　IL-6/NF-kappa　B　signaling,　a　key　driver　of　muscle　atrophy.　Combining　QFG　with　glutamine　(Gln)　further　amplified　these　effects,　suggesting　synergistic　therapeutic　potential.Our　findings　demonstrate　that　QFG　ameliorates　cancer　cachexia　through　microbiota　modulation　and　IL-6/NF-kappa　B　inhibition,　providing　a　novel　multi-targeted　approach　for　cachexia　treatment.