In　the　context　of　the　global　greenhouse　effect　and　energy　scarcity,　it　is　of　great　significance　to　convert　carbon　dioxide　(CO2)　into　value-added　fuels　and　chemicals　through　renewable　electricity.　Cu-based　catalysts　have　been　challenging　for　producing　C-1　and　C2+　high-value　chemicals　in　electrochemical　CO2　reduction　reaction　(CO2RR).　Plenty　of　research　groups　have　engaged　in　the　development　of　Cu-based　catalysts　with　high　activity,　selectivity,　and　stability.　This　review　comprehensively　summarizes　the　recent　progress　in　engineering　Cu-based　catalysts　for　CO2RR,　with　a　detailed　understanding　of　the　reaction　mechanism,　catalyst　design,　and　product　selectivity.　Besides,　the　strategies　aiming　at　improving　the　stability　of　Cu-based　catalysts　and　advancements　in　CO2RR　electrolyzers　are　addressed.　Finally,　the　future　important　research　directions　of　Cu-based　catalysts　in　practical　CO2RR　are　prospected.