Pyroptosis,　an　immunogenic　cell　death　mechanism　triggered　by　Gasdermin　family　proteins,　represents　a　transformative　frontier　in　tumor　immunotherapy.　While　carbon　quantum　dots　(CQDs)　have　emerged　as　pyroptosis-triggering　agents,　their　efficacy　in　NIR-II　light-mediated　therapy　remains　constrained　by　a　low　absorption　coefficient　and　uncontrolled　charge　recombination.　Herein,　CQDs　with　high-density　self-trapped　excitons　(STEs)　exhibiting　NIR-II　absorption　and　an　exceptional　photothermal　conversion　efficiency　of　51.2%　are　engineered.　By　optimizing　the　migration　dynamics　of　hot　carriers,　directional　charge　separation　is　achieved,　which　generates　cytotoxic　hydroxyl　radicals　and　superoxide　radicals.　The　synergistic　photo-thermoelectric　catalysis　triggers　pyroptosis　via　reactive　oxygen　species-caspase　1-gasdermin　D　activation,　eliciting　robust　systemic　immunity　that　effectively　eliminates　the　primary　tumor　and　prevents　tumor　recurrence.　This　work　establishes　STE　engineering　as　a　universal　design　principle　for　advanced　nanomaterials　while　pioneering　a　NIR-II-responsive　pyroptosis　platform　that　bridges　localized　ablation　with　systemic　antitumor　immunity,　offering　a　paradigm　shift　for　precision　immuno-oncology.