Continuous-flow　microfluidic　biochips　(CFMBs),　which　can　automatically　manipulate　fluids　through　microchannels,　have　revolutionary　significance　in　biomedicine,　drug　screening,　and　clinical　diagnosis,　and　have　become　a　hot　topic　in　recent　years.　The　physical　design　directly　affects　the　performance,　reliability,　and　function　realization　of　the　chip.　The　traditional　CFMBs　flow-path　design　used　the　Manhattan　routing.　With　the　increasing　progress　of　the　manufacturing　process,　the　any-angle　routing　of　CFMBs　is　no　longer　a　technical　obstacle,　and　the　any-angle　routing　not　only　improves　the　utilization　rate　of　the　routing　resources,　but　also　reduces　the　length　of　the　flow　channel.　However,　the　existing　any-angle　routing　algorithms　do　not　consider　the　exact　size　of　the　components.　In　this　paper,　A　path-driven　two-stage　any-angle　routing　algorithm　is　proposed　to　minimize　the　routing　length,　considering　the　shape　and　size　of　components.　First,　constrained　delaunay　triangulation　algorithm　is　used　to　construct　search　graphs,　which　considers　the　size　and　shape　of　components,　so　that　the　subsequent　path　search　is　closer　to　the　actual　application　scenario.　And　an　improved　global　routing　based　on　A∗　algorithm　is　adopted　to　obtain　the　initial　path　planning　and　resue　the　fluidic　ports　in　search　graph,　and　then　the　detailed　routing　based　on　dynamic　programming　of　movable　points　is　adopted　to　further　optimize　the　length　of　the　path.　The　experimental　results　show　that　compared　with　the　existing　state-of-art　algorithms,　the　proposed　algorithm　keeps　the　same　numbers　of　fluidic　ports,　and　reduces　the　average　length　of　the　channel　by　5.41%.　©　2025　IEEE.