As　a　populous　country,　how　to　deal　with　the　continuously　growing　massive　volume　of　domestic　waste,　and　how　to　explore　effective　and　sustainable　operation　models　for　the　waste　collection　and　transportation,　are　urgent　research　topics　to　be　addressed.　This　article　focuses　on　optimizing　waste　collection　routes,　aiming　to　reduce　the　total　operation　cost　of　waste　transportation.　Meanwhile,　to　ensure　the　collection　of　waste　in　types,　the　flexible　multi-compartment　vehicles　are　introduced,　to　effectively　promote　the　collection　of　classified　waste.　To　investigate　the　proposed　vehicle　routing　problem　for　waste　collection,　this　article　develops　a　mix-integer　linear　programming　model　for　it.　And　numerical　experiments　on　random　instances　are　conducted　to　verify　the　effectiveness　of　the　model.　Finally,　analysis　of　the　computation　results　obtained　by　applying　the　state-of　art　solver　Gurobi　shown　the　advantage　of　flexible　compartments　to　collect　multiple　types　of　waste.　©　2025　The　Authors.