Clinical　treatment　of　open　wounds　is　challenging　due　to　bacterial　infection　and　biofilm　protection.　Antibiotics　are　commonly　utilized　as　antibacterials;　however,　multidrug　resistance　(MDR)　severely　affects　the　therapeutic　effect.　Therefore,　developing　a　non-antibiotic　strategy　for　treating　infections　and　accelerating　wound　healing　is　highly　required.　Herein,　for　the　first　time,　an　electronically　inverted　antiperovskite,　InNNi3,　has　been　demonstrated　as　a　novel　photothermal　material　with　efficient　and　broad-spectrum　anti-bacterial　activity.　Due　to　the　quasi-continuous　energy　levels　and　inverse　coordination　with　cations/anions　exchanged　in　crystal　sites,　InNNi3　possesses　a　near-unity　photothermal　conversion　efficiency　(96.9%)　and　a　positively　charged　surface,　which　together　contribute　to　the　high　antimicrobial　activity　(99.9%)　via　photothermal　activation　and　electrostatic　interaction　with　pathogens,　including　methicillin-resistant　Staphylococcus　aureus　(MRSA),　Escherichia　coli　(E.　coli)　and　Candida　albicans　(C.　albicans)　within　several　minutes.　Moreover,　as　an　effective　antibiofilm　agent,　InNNi3　exhibits　over　99%　scavenging　effect　on　biofilms.　An　accelerated　healing　rate　for　infected　wounds　has　also　been　achieved　using　an　InNNi3-treatment　strategy　under　NIR　irradiation　by　reducing　inflammation,　promoting　collagen　deposition,　boosting　early　expression　of　CD31　and　facilitating　the　regeneration　of　dermis　and　skin　appendages.　The　excellent　biocompatibility　of　InNNi3　further　demonstrates　its　great　potential　for　clinical　applications　in　future.　©　2025　The　Royal　Society　of　Chemistry.