MXene　is　a　new　type　of　two-dimensional　layered　material　with　unique　physicochemical　properties,　which　has　broad　application　prospects　in　catalysis,　sensing,　energy　storage　and　disease　diagnosis　and　treatment.　With　the　in-depth　development　and　exploration　of　nanotechnology,　the　properties　of　MXene　nanoenzymes　have　been　discovered　and　rapidly　developed,　especially　in　the　diagnosis　and　treatment　of　diseases,　showing　significant　advantages　and　great　application　potential,　which　is　expected　to　bring　new　breakthroughs　for　the　scientific　and　technological　progress　and　industrial　development　in　this　field.　In　this　review,　we　summarize　the　research　progress　of　MXene　nanoenzymes　in　disease　diagnosis　and　treatment.　The　article　firstly　introduces　the　preparation　method,　surface　modification　and　enzyme-like　activity　of　MXene,　and　secondly　focuses　on　the　application　of　MXene-based　nanoenzymes　in　biosensing,　bioimaging,　antibacterial,　cancer　therapy　and　other　diseases.　It　finally　concludes　with　a　discussion　of　the　current　status　of　MXene　nanoenzymes　in　disease　diagnosis　and　treatment,　potential　applications,　and　new　challenges　and　opportunities　for　future　development.　MXene　nanoenzymes　will　become　an　important　material　for　the　diagnosis　and　treatment　of　diseases　in　the　future.　©　2025　Beijing　University　of　Aeronautics　and　Astronautics　(BUAA).　All　rights　reserved.