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Abstract:
A silver-catalyzed synthesis of 5-aryl-3-trifluoromethyl pyrazoles from reaction of various N'-benzylidene tolylsulfonohydrazides with ethyl 4,4,4-trifluoro-3-oxobutanoate is described. The reaction proceeds via sequential nucleophilic addition, intramolecular cyclization, elimination, and [1,5]-H shift steps to afford the trifluoromethylated pyrazole products in moderate to excellent yields. The reaction is compatible with a variety of functional groups. (C) 2019 Elsevier Ltd. All rights reserved.
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TETRAHEDRON LETTERS
ISSN: 0040-4039
Year: 2020
Issue: 5
Volume: 61
2 . 4 1 5
JCR@2020
1 . 5 0 0
JCR@2023
ESI Discipline: CHEMISTRY;
ESI HC Threshold:160
JCR Journal Grade:3
CAS Journal Grade:4
Cited Count:
WoS CC Cited Count: 15
SCOPUS Cited Count: 17
ESI Highly Cited Papers on the List: 0 Unfold All
WanFang Cited Count:
Chinese Cited Count:
30 Days PV: 0
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