A　method　for　the　synthesis　of　polysubstituted　4-difluoromethyl　and　perfluoroalkyl　pyrazole　derivatives　by　the　Lewis　acid-　and　base-co-mediated　reaction　of　perfluoroacetyl　diazoester　with　ketones　is　reported.　A　series　of　structurally　diverse　4-difluoromethylated　and　perfluoroalkylated　pyrazoles　were　obtained　in　moderate　to　good　yields.　The　reactions　proceeded　smoothly　under　mild　conditions　with　wide　functional　group　tolerance.　(C)　2021　Elsevier　Ltd.　All　rights　reserved.