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author:

Zhang, Lu (Zhang, Lu.) [1] | Wang, Jun (Wang, Jun.) [2] | Zhang, Yingying (Zhang, Yingying.) [3] | Ke, Linjie (Ke, Linjie.) [4] | Lin, Xiaowen (Lin, Xiaowen.) [5] | Li, Ziying (Li, Ziying.) [6] | Chen, Haijun (Chen, Haijun.) [7] (Scholars:陈海军) | Gao, Yu (Gao, Yu.) [8] (Scholars:高瑜)

Indexed by:

EI Scopus SCIE

Abstract:

The outcome of application of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) in patients with non-small-cell lung cancer (NSCLC) always suffers from acquired drug resistance. Its combination with other therapies has been explored with promising synergistic results. Photodynamic therapy (PDT) is an established treatment modality for NSCLC, but the low tumor selectivity of currently available photosensitizers (PSs) hampered the wide clinical application of PDT. Here, we synthesized erlotinib modified chitosan (ECs) by click coupling and developed ECs/indocyanine green (ICG) self-assembled nanoparticles (GECs) for combined targeted chemo-photodynamic therapy. GECs showed oval-shaped particles with a diameter of 267.5 nm, a zeta potential of -15.2 mV, and considerable photostability. In vitro release experiment showed that erlotinib and ICG could be slowly released from GECs in acidic condition with lysozyme. GECs were capable of generating reactive oxygen species (ROS) for PDT under near-infrared laser irradiation. GECs showed synergistic molecular targeted and photodynamic therapeutic effects in inhibition of cellular growth and induction of apoptosis in NSCLC cells. This study demonstrated that the GECs could be a promising platform by combination of targeted chemo-photodynamic therapy for NSCLC treatment.

Keyword:

Chitosan Erlotinib Indocyanine green NSCLC Photodynamic therapy

Community:

  • [ 1 ] [Zhang, Lu]Fuzhou Univ, Coll Chem, Biopharmaceut Photocatalysis State Key Lab Photoc, Canc Metastasis Alert & Prevent Ctr, Fuzhou 350108, Fujian, Peoples R China
  • [ 2 ] [Wang, Jun]Fuzhou Univ, Coll Chem, Biopharmaceut Photocatalysis State Key Lab Photoc, Canc Metastasis Alert & Prevent Ctr, Fuzhou 350108, Fujian, Peoples R China
  • [ 3 ] [Zhang, Yingying]Fuzhou Univ, Coll Chem, Biopharmaceut Photocatalysis State Key Lab Photoc, Canc Metastasis Alert & Prevent Ctr, Fuzhou 350108, Fujian, Peoples R China
  • [ 4 ] [Ke, Linjie]Fuzhou Univ, Coll Chem, Biopharmaceut Photocatalysis State Key Lab Photoc, Canc Metastasis Alert & Prevent Ctr, Fuzhou 350108, Fujian, Peoples R China
  • [ 5 ] [Lin, Xiaowen]Fuzhou Univ, Coll Chem, Biopharmaceut Photocatalysis State Key Lab Photoc, Canc Metastasis Alert & Prevent Ctr, Fuzhou 350108, Fujian, Peoples R China
  • [ 6 ] [Li, Ziying]Fuzhou Univ, Coll Chem, Biopharmaceut Photocatalysis State Key Lab Photoc, Canc Metastasis Alert & Prevent Ctr, Fuzhou 350108, Fujian, Peoples R China
  • [ 7 ] [Gao, Yu]Fuzhou Univ, Coll Chem, Biopharmaceut Photocatalysis State Key Lab Photoc, Canc Metastasis Alert & Prevent Ctr, Fuzhou 350108, Fujian, Peoples R China
  • [ 8 ] [Zhang, Lu]Fuzhou Univ, Fujian Prov Key Lab Canc Metastasis Chemoprevent, Fuzhou 350108, Fujian, Peoples R China
  • [ 9 ] [Wang, Jun]Fuzhou Univ, Fujian Prov Key Lab Canc Metastasis Chemoprevent, Fuzhou 350108, Fujian, Peoples R China
  • [ 10 ] [Zhang, Yingying]Fuzhou Univ, Fujian Prov Key Lab Canc Metastasis Chemoprevent, Fuzhou 350108, Fujian, Peoples R China
  • [ 11 ] [Ke, Linjie]Fuzhou Univ, Fujian Prov Key Lab Canc Metastasis Chemoprevent, Fuzhou 350108, Fujian, Peoples R China
  • [ 12 ] [Lin, Xiaowen]Fuzhou Univ, Fujian Prov Key Lab Canc Metastasis Chemoprevent, Fuzhou 350108, Fujian, Peoples R China
  • [ 13 ] [Li, Ziying]Fuzhou Univ, Fujian Prov Key Lab Canc Metastasis Chemoprevent, Fuzhou 350108, Fujian, Peoples R China
  • [ 14 ] [Chen, Haijun]Fuzhou Univ, Fujian Prov Key Lab Canc Metastasis Chemoprevent, Fuzhou 350108, Fujian, Peoples R China
  • [ 15 ] [Gao, Yu]Fuzhou Univ, Fujian Prov Key Lab Canc Metastasis Chemoprevent, Fuzhou 350108, Fujian, Peoples R China

Reprint 's Address:

  • 高瑜

    [Gao, Yu]Fuzhou Univ, 2 Xueyuan Rd,Yangguang Bldg,6FL, Fuzhou 350108, Fujian, Peoples R China

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Source :

DYES AND PIGMENTS

ISSN: 0143-7208

Year: 2019

Volume: 170

4 . 6 1 3

JCR@2019

4 . 1 0 0

JCR@2023

ESI Discipline: CHEMISTRY;

ESI HC Threshold:184

JCR Journal Grade:1

CAS Journal Grade:1

Cited Count:

WoS CC Cited Count: 26

SCOPUS Cited Count: 26

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 2

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