Polybrominated　diphenyl　ethers　(PBDEs)　are　widely　used　as　flame　retardants　and　challenges　for　water　treatment　due　to　their　persistence　and　toxicity.　In　this　study,　the　reduction　of　2＇2＇4＇4＇-tetrabromodiphenyl　ether　(BDE-47)　was　investigated　in　a　nano-bio-integrated　system.　Results　showed　that　the　introducing　of　P.　putida　could　markedly　accelerate　the　demineralization　of　BDE-47　in　nZVI/Pd-P.p　system;　the　continuous　generation　of　acidic　metaboliates　by　P.　putida　could　decrease　pH,　which　could　alleviate　the　surface　passivation　to　some　extent,　resulting　in　the　releasing　of　Fe2+　and　high　generation　of　H2O2,　the　shift　in　reactive　oxygen　species　from　Fe(IV)　to　center　dot　OH.　The　BDE-47　was　firstly　debrominated　to　the　DE　by　the　highly　reductive　[Pd　center　dot　2H]　generated　by　nZVI/Pd,　then　oxidized　to　bromophenol　and　phenol,　catechol　as　well　as　hydroquinone　via　the　P.　putida　strain　and　the　Fenton-like　system.　The　toxicity　assays　confirmed　the　combined　system　could　avert　generation　of　nocuous　intermediates,　and　could　be　an　alternative　strategy　for　complete　remediation　of　recalcitrant　POPs.　(C)　2019　Elsevier　Ltd.　All　rights　reserved.