In　this　paper,　we　study　the　cooperative　output　regulation　problem　for　a　class　of　general　linear　uncertain　multi-input　multi-output　(MIMO)　multi-agent　systems　subject　to　a　well-defined　vector　relative　degree.　By　proposing　some　suitable　internal　model,　the　problem　is　first　converted　into　the　auxiliary　cooperative　stabilization　problem　of　the　augmented　system　in　the　so-called　strict　feedback　normal　form.　This　auxiliary　problem　is　then　solved　by　some　developed　robust　control　techniques,　such　as　multiple　high-gain　feedback　and　mixed　distributed　observer,　leading　to　an　effective　distributed　output　feedback　regulator　synthesis　for　the　original　cooperative　output　regulation　problem.