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author:

Wang, Jianhua (Wang, Jianhua.) [1] (Scholars:王建华) | Zhang, Zhihua (Zhang, Zhihua.) [2] | Su, Guanghao (Su, Guanghao.) [3] | Sun, Xiaomin (Sun, Xiaomin.) [4] | Wang, Yingying (Wang, Yingying.) [5] | Fang, Zhexiang (Fang, Zhexiang.) [6] | Chen, Mingmao (Chen, Mingmao.) [7] (Scholars:陈名懋) | Zhang, Qiqing (Zhang, Qiqing.) [8]

Indexed by:

Scopus SCIE

Abstract:

We present the synthesis of graphene oxide (GO) via the modified Hummer method and nanocomposites based on collagen/ nano-hydroxyapatite (COL/nHA). GO was prepared by freeze drying the stable mixture of the components. Comprehensive characterizations of the properties of GO were conducted by X-ray diffraction and Fourier-transform infrared spectra analyzer. Effects of the incorporation of GO on morphology, phase structure, and wear resistance of the resulting composite coatings were evaluated in detail. FT-IR results show that the GO and nHA disperse homogeneously in the composite. COL/GO/nHA composites with high porosity were confirmed by scanning electron microscope and porosity test. By increasing the GO content from 0 to 4 wt%, COL/GO/nHA composites exhibited improved hydrophilic and mechanical properties. The cell viability and proliferation results showed that osteoblastic cells can adhere and develop on COL/GO/nHA composites. An outstanding proliferation potential was displayed by the cells in contact with COL/GO/nHA 4 wt%. The GO-reinforced COL/nHAs with high mechanical and bioactive properties are potential candidates for bone tissue engineering.

Keyword:

Collagen Graphene Oxide Nano-Hydroxyapatite Osteoblasts

Community:

  • [ 1 ] [Wang, Jianhua]Fuzhou Univ, Inst Biomed & Pharmaceut Technol, Fuzhou 350002, Fujian, Peoples R China
  • [ 2 ] [Zhang, Zhihua]Fuzhou Univ, Inst Biomed & Pharmaceut Technol, Fuzhou 350002, Fujian, Peoples R China
  • [ 3 ] [Sun, Xiaomin]Fuzhou Univ, Inst Biomed & Pharmaceut Technol, Fuzhou 350002, Fujian, Peoples R China
  • [ 4 ] [Wang, Yingying]Fuzhou Univ, Inst Biomed & Pharmaceut Technol, Fuzhou 350002, Fujian, Peoples R China
  • [ 5 ] [Fang, Zhexiang]Fuzhou Univ, Inst Biomed & Pharmaceut Technol, Fuzhou 350002, Fujian, Peoples R China
  • [ 6 ] [Chen, Mingmao]Fuzhou Univ, Inst Biomed & Pharmaceut Technol, Fuzhou 350002, Fujian, Peoples R China
  • [ 7 ] [Zhang, Qiqing]Fuzhou Univ, Inst Biomed & Pharmaceut Technol, Fuzhou 350002, Fujian, Peoples R China
  • [ 8 ] [Su, Guanghao]Soochow Univ, Childrens Hosp, Inst Pediat Res, Suzhou 215025, Peoples R China

Reprint 's Address:

  • 张其清

    [Zhang, Qiqing]Fuzhou Univ, Inst Biomed & Pharmaceut Technol, Fuzhou 350002, Fujian, Peoples R China

Email:

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Source :

JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING

ISSN: 2157-9083

Year: 2017

Issue: 10

Volume: 7

Page: 1000-1007

0 . 7 8 1

JCR@2017

0 . 1 0 0

JCR@2022

ESI Discipline: BIOLOGY & BIOCHEMISTRY;

ESI HC Threshold:231

JCR Journal Grade:4

CAS Journal Grade:4

Cited Count:

WoS CC Cited Count: 13

SCOPUS Cited Count: 14

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 1

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