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Abstract:
We present the synthesis of graphene oxide (GO) via the modified Hummer method and nanocomposites based on collagen/ nano-hydroxyapatite (COL/nHA). GO was prepared by freeze drying the stable mixture of the components. Comprehensive characterizations of the properties of GO were conducted by X-ray diffraction and Fourier-transform infrared spectra analyzer. Effects of the incorporation of GO on morphology, phase structure, and wear resistance of the resulting composite coatings were evaluated in detail. FT-IR results show that the GO and nHA disperse homogeneously in the composite. COL/GO/nHA composites with high porosity were confirmed by scanning electron microscope and porosity test. By increasing the GO content from 0 to 4 wt%, COL/GO/nHA composites exhibited improved hydrophilic and mechanical properties. The cell viability and proliferation results showed that osteoblastic cells can adhere and develop on COL/GO/nHA composites. An outstanding proliferation potential was displayed by the cells in contact with COL/GO/nHA 4 wt%. The GO-reinforced COL/nHAs with high mechanical and bioactive properties are potential candidates for bone tissue engineering.
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JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING
ISSN: 2157-9083
Year: 2017
Issue: 10
Volume: 7
Page: 1000-1007
0 . 7 8 1
JCR@2017
0 . 1 0 0
JCR@2022
ESI Discipline: BIOLOGY & BIOCHEMISTRY;
ESI HC Threshold:231
JCR Journal Grade:4
CAS Journal Grade:4
Cited Count:
WoS CC Cited Count: 13
SCOPUS Cited Count: 14
ESI Highly Cited Papers on the List: 0 Unfold All
WanFang Cited Count:
Chinese Cited Count:
30 Days PV: 1
Affiliated Colleges: