In　this　study,　we　report　a　new　strategy　for　the　synthesis　of　2,4-disubstituted　pyrroles　using　a　stepwise　iododesilylation　and　palladium-catalysed　Suzuki　coupling　reaction　of　2,4-bis(trimethylsilyl)-1-t-Boc-1H-pyrrole　(2).　The　regioselective　iodo-desilylation　followed　by　the　Suzuki　coupling　reaction　with　concomitant　Boc　deprotection　are　critical　aspects　of　the　new　synthesis　method.　(C)　2016　Elsevier　Ltd.　All　rights　reserved.