A　pressure-assisted　CEC　(pCEC)　with　ESI-MS　based　on　silica-based　monolithic　column　was　developed　for　rapid　analysis　of　narcotics.　Combining　the　extremely　high　permeability　and　separation　efficiency　of　silica-based　monolithic　column　with　the　high　selectivity　and　sensitivity　of　pCEC-ESI-MS,　the　developed　system　exhibited　its　prominent　advantages　in　separation　and　detection.　A　systematic　investigation　of　the　pCEC　separation　and　ESI-MS　detection　parameters　was　performed.　Experiment　results　showed　that　the　optimized　separation　efficiency　could　be　obtained　at　8　bar　assisted　pressure　with　25　kV　separation　voltage,　using　the　solution　containing　65%　ACN　v/v　and　20　mmol/L　ammonium　acetate　with　pH　6.0　as　running　buffer.　3　mu　L/min　of　sheath　liquid　was　considered　as　the　optimized　flow　rate　since　it　could　provide　the　maximum　signal　intensity.　Under　the　optimum　conditions,　the　tested　five　narcotics　could　be　completely　separated　within　10　min　with　the　detection　limit　in　the　range　of　2.0-80　nmol/L.　The　proposed　method　has　been　successfully　used　for　detection　of　narcotics　in　real　urine　samples.