Two　novel　morpholine-containing　silicon　(IV)　phthalocyanines,　namely　bis　(2-morpholine)　ethoxy　phthalocyaninatosilicon　(2)　and　bis　(2-(N-methyl-morpholine))　ethoxy　phthalocyaninatosilicon　diiodide　(3),　have　been　prepared.　The　complexations　of　these　two　compounds　with　three　serum　proteins　including　the　bovine　serum　albumin,　human　serum　albumin,　and　transferrin　have　also　been　investigated.　The　non-aggregated　compound　3　exhibits　a　high　photodynamic　activity　towards　B16　melanoma　tumour　cells　with　an　IC50　value　of　0.30　mu　M.　(C)　2006　Elsevier　B.V.　All　rights　reserved.