Eight　enkephalin-related　peptides　were　derivatized　using　fluorescein　isothiocyanate　(FITC),　and　the　derivatization　products　were　separated　and　detected　by　capillary　electrophoresis　with　laser-induced　fluorescence　detection.　The　optimum　molar　ratio　of　FITC　and　peptide　for　derivatization　was　found　to　be　40:1,　and　5　mmol/L　sodium　borate　buffer　(pH　9.2)　was　selected　as　derivatization　media　in　order　to　get　the　high　efficiency.　Enkephalin-related　peptides　were　completely　separated　in　the　pH　range　of　10.51-10.60　in　a　running　buffer　consisting　of　100　mmol/L　sodium　borate　and　60　mmol/L　sodium　dodecyl　sulfate　(SDS).　The　detection　limit　for　these　eight　enkephalins　ranged　from　0.18　to　2.25　nmol/L,　and　the　linear　response　range　was　1.0　x　10(-6)　to　1.0　x　10(-9)　mol/L　with　correlation　coefficients　between　0.9947-0.9988.　A　separation　efficiency　as　high　as　380　000　theoretical　plates　could　be　obtained　for　these　analytes.