Acupuncture　therapy　is　an　often-used　traditional　Chinese　medicine　intervention　of　autism　spectrum　disorder.　Acupuncture　is　usually　delivered　by　therapists;　thus,　its　effectiveness　highly　relies　on　their　experience.　This　paper　designed　a　closed-loop　electrical　stimulation　treatment　system　triggered　by　neurophysiological　signals,　in　order　to　improve　the　conventional　acupuncture　in　clinical　trials.　Electrooculogram　(EOG)　signals　are　collected　and　analyzed　synchronously　while　autistic　children　are　watching　the　specifically　designed　visual　evocation　system.　The　electrical　stimulation　is　triggered　once　the　attention　state　is　determined,　delivering　stimulation　to　the　Changqiang　acupoint　(between　the　tailbone　and　the　anus).　Three　healthy　volunteers　and　four　autistic　children　participated　in　this　proof-of-concept　study.　Prior　to　the　online　test,　the　subject-special　EOG　template　was　determined　offline.　We　obtained　the　mean　recognition　rate　of　95.45%　for　healthy　participants　and　89.43%　for　autistic　children,　and　the　mean　false　recognition　rate　of　2.51%　for　healthy　participants　and　7.23%　for　autistic　children　by　template　matching　algorithm.　The　system　was　able　to　recognize　the　EOG　pattern　of　attention　to　the　state　and　successfully　trigger　the　electrical　stimulation.　This　study　is　the　first　time　to　combine　acupuncture　and　bioelectrical　signal　to　provide　an　automatic　closed-loop　electrical　stimulation　system　for　acupuncture　therapy.　©　2020,　©　2020　The　Author(s).　Published　by　Informa　UK　Limited,　trading　as　Taylor　&　Francis　Group.