In　order　to　explore　the　impact　of　auxiliary　hypoglycemic　of　superoxide　dismutase　(SOD)　by　Maillard　reaction,　based　on　bovine　blood　SOD　as　raw　material,　added　glucose　for　non-enzymatic　glycation　reaction,　the　glycated　SOD　(SOD-G)　and　single　bovine　blood　SOD　were　used　to　treat　alloxan-induced　diabetic　rats,　to　compare　the　effect　of　weight,　blood　glucose,　oral　glucose　tolerance,　the　SOD　levels　of　tissue　organs　(Heart,　liver,　kidney,　pancreas　and　skeletal　muscle)　and　the　level　of　plasma　insulin　(INS),　amp　activated　protein　kinase　(AMPK)　and　malondialdehyde　(MDA)　of　diabetic　rats　given　SOD　and　an　equal　dose　of　SOD-G,　as　well　as　different　doses　of　SOD-G.　The　test　results　show　that　SOD-G　and　SOD　have　a　significant　effect　on　reduction　of　blood　glucose　in　alloxan-induced　type　I　diabetic　rats,　but　each　has　its　advantages.　There　are　no　differences　in　body　weight　control.　SOD-G　hypoglycemic　effect　is　significantly　better　than　SOD　(P　©　2018,　Editorial　Office　of　Journal　of　CIFST.　All　right　reserved.