As　continuing　development　of　information　communication　technology,　libraries　are　experiencing　a　transformation　from　a　book-centered　to　a　user-centered　place　that　leads　to　users’　activities　becoming　more　diversified.　Consequently,　the　library　interior　space　changes　from　simple　to　diverse;　from　close　to　open.　It　emphasizes　more　the　possibilities　of　space　adaptability,　flexibility　and　replacement.　Under　the　conception　of　＇user-centered　approach＇,　the　library　design　has　to　reveal　affinity,　exchange　and　atmosphere　characteristics.　This　article　employs　the　new　library　interior　space　of　Yangtze　University　as　case　study　to　further　interpret　spatial　design　under　the　concern　of　changing　activities　from　users.　©　2015　Taylor　&　Francis　Group,　London.