The　serious　problem　of　pharmaceutical　and　personal　care　product　pollution　places　great　pressure　on　aquatic　environments　and　human　health.　Herein,　a　novel　coating　photocatalyst　was　synthesized　by　adhering　Ag-AgCl/WO3/g-C3N4　(AWC)　nanoparticles　on　a　polydopamine　(PDA)-modified　melamine　sponge　(MS)　through　a　facile　layer-by-layer　assembly　method　to　degrade　trimethoprim　(TMP).　The　formed　PDA　coating　was　used　for　the　anchoring　of　nanoparticles,　photothermal　conversion,　and　hydrophilic　modification.　TMP　(99.9%;　4　mg/L)　was　removed　in　90　min　by　the　photocatalyst　coating　(AWC/PDA/MS)　under　visible　light　via　a　synergistic　photocatalytic-photothermal　performance　route.　The　stability　and　reusability　of　the　AWC/PDA/MS　have　been　proved　by　cyclic　experiments,　in　which　the　removal　efficiency　of　TMP　was　still　more　than　90%　after　five　consecutive　cycles　with　a　very　little　mass　loss.　Quantitative　structure-activity　relationship　analysis　revealed　that　the　ecotoxicities　of　the　generated　intermediates　were　lower　than　those　of　TMP.　Furthermore,　the　solution　matrix　effects　on　the　photocatalytic　removal　efficiency　were　investigated,　and　the　results　revealed　that　the　AWC/PDA/MS　still　maintained　excellent　photocatalytic　degradation　efficiency　in　several　actual　water　and　simulated　water　matrices.　This　work　develops　recyclable　photocatalysts　for　the　potential　application　in　the　field　of　water　remediation.