Dengue　virus　(DENV)　is　a　small　envelope　virus　of　Flaviviridae　that　is　mainly　transmitted　by　Aedes　aegypti　and　Aedes　albopictus.　It　can　cause　dengue　fever　with　mild　clinical　symptoms　or　even　life-threatening　dengue　hemorrhagic　fever　(DHF)　and　dengue　shock　syndrome　(DSS).　At　present,　there　are　no　specific　drugs　or　mature　vaccine　products　to　treat　DENV.　microRNAs　(miRNAs)　are　a　class　of　important　non-coding　small　molecular　RNAs　that　regulate　gene　expression　at　the　post-transcriptional　level.　It　is　involved　in　and　regulates　a　series　of　important　life　processes,　such　as　growth　and　development,　cell　differentiation,　cell　apoptosis,　anti-virus,　and　anti-tumor.　miRNAs　also　play　important　roles　in　interactions　between　host　and　viral　genome　transcriptomes.　Host　miRNAs　can　directly　target　the　genome　of　the　virus　or　regulate　host　factors　to　promote　or　inhibit　virus　replication.　Understanding　the　expression　and　function　of　miRNAs　during　infection　with　DENV　and　the　related　signal　molecules　of　the　miRNA-mediated　regulatory　network　will　provide　new　insights　for　the　development　of　miRNA-based　therapies.