Metabolic　syndrome　is　a　cluster　of　metabolic　disorders　that　threatens　public　health.　Nevertheless,　its　exact　mechanism　and　relative　intervention　remain　largely　obscure.　Accumulating　evidence　indicate　that　tither　Anoectochilus　roxburghii　polysaccharide　(ARP)　or　exercise　(EX)　exhibited　the　beneficial　effects　on　metabolic　health.　However,　the　synergetic　beneficial　effects　of　ARP　and　EX　as　a　combined　intervention　on　obesity-induced　metabolic　disorders　remain　largely　obscure.　Male　C57BL/6　mice　were　fed　a　high-fat　diet　(HFD)　and　intervened　with　ARP　and　EX　for　12　continuous　weeks.　The　results　indicated　that　the　ARP,　EX,　and　ARP　combined　with　EX　treatment　group　regulated　lipogenesis　by　suppressing　the　fatty　acid　pathway,　dampening　the　system　oxidative　stress　by　stimulating　Nrf2-mediated　phase　II　enzyme　system,　and　promoting　the　mitochondrial　function　by　activating　the　mitochondrial　complexes　and　PGC-1　alpha　in　HFD　mice.　More　importantly,　the　combination　of　ARP　and　EX　showed　an　even　greater　beneficial　effects　relative　to　either　ARP　or　EX　alone,　especially　in　decreasing　reactive　oxygen　species　(ROS)　level　and　increasing　adenosine　triphosphate　(ATP)　content.　Taken　together,　these　findings　further　confirmed　that　ARP　and　EX　could　be　effective　interventions　on　obesity-induced　metabolic　abnormalities,　and　that　the　combination　of　ARP　and　EX　exhibited　the　beneficial　synergetic　effects.