As　a　novel　kind　of　two　dimensional　material.　MXene　refers　to　the　family　of　two-dimensional　transition　metal　carbides.　nitrides　or　carbonitrides.　The　general　formula　of　this　material　is　Mn+1　X-n　T-x(n　=　1　similar　to　3)　where　M　is　transitional　metal.　X　is　carbon　or　nitrogen　and　T　is　active　functional　groups　such　as　fluorine.　hydroxyl　or　oxygen-containing　group.　The　ultra.　thin　structure　and　fascinating　physical　and　chemical(　electronic.　optical.　magnetic.　etc.)　properties　of　this　material　has　attracted　wide　interest　in　mechanical　engineering.　optics.　energy.　and　electronics　areas.　Currently.　MXenes　are　broadening　their　applications　in　the　biomedical　field.　This　is　mainly　originated　from　their　large　surface　area　and　strong　absorbance　in　near-infrared　region.　combining　with　their　facile　surface　modifications　with　various　molecular　or　nanoparticles.　This　review　introduces　the　very　recent　progress　and　novel　paradigms　of　MXenes　for　state-of-the-art　biomedical　applications.　Firstly.　the　preparation　methods　and　surface　modifications　of　MXenes　designed　for　biomedical　applications　is　introduced.　Then　their　applications　in　the　biomedical　areas　are　emphasized.　including　structural.　and　dose-dependent　antimicrobial　activity.　bioimaging.　photothermal　cancer　therapy.　precise　biosensors　and　so　on.　Finally.　the　current　challenges　and　future　opportunities　of　applying　MXene-based　nanomaterials　and　nanocomposites　in　biomedical　field　are　summarized　and　discussed.　It　is　highly　expected　that　the　ultrathin　MXenes　and　their　elaborately　designed　nanocomposites　will　become　one　of　the　most　attractive　biocompatible　inorganic　nano-platforms　for　multiple　and　extensive　biomedical　applications.