Anode　materials　play　a　critical　role　in　enhancement　of　lithium-ion　batteries　(LIBs)　toward　high　energy　density.　In　this　work,　the　hollow　Cu2O　nanospheres　with　surface　{111}　and　{110}　active　facets　and　intraluminal　Cu2O　nanoparticles　are　synthesized　using　a　simple　and　low-cost　one-step　method,　and　used　as　the　anode　materials　for　LIBs　to　achieve　high　performance.　Some　advanced　spectroscopic　characterization　and　electrochemical　methods　are　employed　for　fundamentally　understanding　the　relationship　between　structure/morphology/composition　and　electrochemical　performance.　Using　these　materials,　the　as-fabricated　anodes　can　deliver　an　excellent　specific　capacity　of　914.4　Ah.kg−1　at　a　current　density　of　1　C　(375　A.kg−1)　after　390　cycles,　and　even　at　a　large　current　density　of　10　C,　the　capacity　retention　is　still　as　high　as　356.7　Ah.kg−1.　The　enhancement　in　battery　performance　is　attributed　to　the　novel　structure　of　Cu2O-HNs　anode　materials　with　high　surface　area,　high　surface　active　{111}　and　{110}　facets　and　the　intraluminal　Cu2O　nanoparticles.　The　outstanding　electrochemical　performance　achieved　in　this　work　demonstrates　a　high　potential　of　Cu2O-HNs　to　be　applied　as　high-energy　anode　materials　for　practical　lithium-ion　batteries.　©　2022　Elsevier　B.V.