Synthesis of 3-substituted 2-trifluomethyl imidazo[1,2-a]pyridine through [3+2] cycloaddition of pyridinium ylide with trifluoroacetonitrile - Details

author：

Hong, B.;, Lin, B.;, Yao, Y.;, Li, S.;, Weng, Z. (Hong, B.;, Lin, B.;, Yao, Y.;, Li, S.;, Weng, Z..) ^[1]

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Abstract：

A　general　approach　to　prepare　2-trifluoromethyl　imidazo[1,2-a]pyridines　by　a　[3+2]　cycloaddition　of　pyridinium　ylide　with　trifluoroacetonitrile　is　described.　By　using　2,2,2-trifluoroacetaldehyde　O-(aryl)oxime　as　convenient　precursor　of　trifluoroacetonitrile,　the　reaction　exhibits　a　broad　substrate　scope　of　pyridinium　ylides.　The　process　is　a　scalable　method　for　the　synthesis　of　potentially　bioactive　class　of　2-trifluoromethyl　imidazo[1,2-a]pyridines.　©　2022　Elsevier　Ltd

Keyword：

2-a]pyridines Cycloaddition Imidazo[1 Synthetic methods Trifluomethylation Trifluoroacetonitrile

Community：

[ 1 ] [Hong B.]Fujian Engineering Research Center of New Chinese Lacquer Material, College of Materials and Chemical Engineering, Minjiang University, Fuzhou, 350108, China
[ 2 ] [Lin B.]Key Laboratory of Molecule Synthesis and Function Discovery, Fujian Provincial Key Laboratory of Electrochemical Energy Storage Materials, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 3 ] [Yao Y.]Key Laboratory of Molecule Synthesis and Function Discovery, Fujian Provincial Key Laboratory of Electrochemical Energy Storage Materials, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 4 ] [Li S.]Fujian Engineering Research Center of New Chinese Lacquer Material, College of Materials and Chemical Engineering, Minjiang University, Fuzhou, 350108, China
[ 5 ] [Weng Z.]Fujian Engineering Research Center of New Chinese Lacquer Material, College of Materials and Chemical Engineering, Minjiang University, Fuzhou, 350108, China
[ 6 ] [Weng Z.]Key Laboratory of Molecule Synthesis and Function Discovery, Fujian Provincial Key Laboratory of Electrochemical Energy Storage Materials, College of Chemistry, Fuzhou University, Fuzhou, 350108, China

Reprint 's Address：

[Weng, Z.]Fujian Engineering Research Center of New Chinese Lacquer Material, China

Email：

zweng@fzu.edu.cn

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Related Keywords：

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Source ：

Tetrahedron Letters

ISSN： 0040-4039

Year： 2022

Volume： 111

1 . 8

JCR@2022

1 . 5 0 0

JCR@2023

ESI HC Threshold：74

JCR Journal Grade：3

CAS Journal Grade：4

Cited Count：

WoS CC Cited Count： 0

SCOPUS Cited Count： 4

ESI Highly Cited Papers on the List： 0 Unfold All

WanFang Cited Count：

Chinese Cited Count：

30 Days PV： 0

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