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author：

Chen, Y. (Chen, Y..) [1] | Lin, S. (Lin, S..) [2] | Lai, J. (Lai, J..) [3] | Wang, Q. (Wang, Q..) [4] | Lin, J. (Lin, J..) [5] | Ao, W. (Ao, W..) [6] | Ye, H. (Ye, H..) [7] | Han, X. (Han, X..) [8]

Indexed by：

Scopus

Abstract：

The　HIV　latent　reservoir　is　the　main　obstacle　to　the　eradication　of　AIDS.　Recent　studies　have　shown　that　the　RNA　m6A　is　involved　in　the　regulation　of　HIV-1　replication.　However,　no　relevant　study　has　reported　the　relationship　between　RNA　m6A　and　HIV　latent　reservoir.　For　this　purpose,　peripheral　blood　mononuclear　cell　(PBMC)　was　collected　from　36　HIV-infected　patients　at　1,　24,　and　48　weeks　after　treatment　initiation.　The　number　of　CD4+　and　CD8+　T　cells　was　detected　by　flow　cytometry.　Amount　of　HIV　DNA　in　the　PBMC　samples　one　week　after　treatment　initiation　was　detected　by　Q-PCR.　The　expression　levels　of　23　RNA-m6A-related　genes　were　detected　by　Q-PCR　and　Pearson＇s　correlation　analysis　was　performed.　Results　showed　that　there　was　a　negative　correlation　between　HIV　DNA　concentration　and　the　number　of　CD4+　T　cells　(r=-0.32,　p=0.05;　r=-0.32,　p=0.06)　and　a　positive　correlation　with　the　number　of　CD8+　T　cells　(r=0.48,　p=0.003;　r=0.37,　p=0.03).　Furthermore,　a　negative　correlation　was　observed　between　HIV　DNA　concentration　and　the　CD4+/CD8+　T　cell　ratio　(r=-0.53,　p=0.001;　r=-0.51,　p=0.001).　RNAm6A　related　genes　which　correlated　with　HIV　DNA　concentration　includedALKBH5　(r=-0.45,　p=-0.006),　METTL3　(r=0.73,　p=2.76e-7),　METTL16　(r=0.71,　p=1.21e2.76e-06),　YTHDF1　(r=0.47,　p=0.004).　Moreover,　they　have　different　degrees　of　correlation　with　numbers　ofCD4+　and　CD8+　T　cell　subsets,　and　the　CD4+/CD8+T　cell　ratio.　In　addition,　the　expression　of　RBM15　was　not　correlated　with　HIV　DNA　concentration　but　was　significantly　negatively　correlated　with　the　number　of　CD4+T　cells　(r=-0.40,　p=0.02).　In　conclusion,　the　expression　of　ALKBH5,　METTL3,　and　METTL16　is　correlated　with　the　HIV　DNA　level,　the　levels　of　CD4+　and　CD8+　T　cell　counts,　and　the　CD4+/CD8+　T　cell　ratio.　RBM15　is　independent　of　HIV　DNA　level　and　negatively　correlated　with　the　number　of　CD4+T　cells.

Keyword：

ALKBH5 HIV latent reservoir METTL16 METTL3 RNA m6A

Community：

  • [ 1 ] [Chen Y.]Infectious Department, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
  • [ 2 ] [Chen Y.]Infectious Department, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
  • [ 3 ] [Chen Y.]Infectious Department, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
  • [ 4 ] [Chen Y.]Infectious Department, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
  • [ 5 ] [Chen Y.]Infectious Department, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
  • [ 6 ] [Lin S.]Infectious Department, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
  • [ 7 ] [Lin S.]Infectious Department, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
  • [ 8 ] [Lin S.]Infectious Department, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
  • [ 9 ] [Lin S.]Infectious Department, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
  • [ 10 ] [Lin S.]Infectious Department, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
  • [ 11 ] [Lai J.]Infectious Department, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
  • [ 12 ] [Lai J.]Infectious Department, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
  • [ 13 ] [Lai J.]Infectious Department, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
  • [ 14 ] [Lai J.]Infectious Department, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
  • [ 15 ] [Lai J.]Infectious Department, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
  • [ 16 ] [Wang Q.]Infectious Department, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
  • [ 17 ] [Wang Q.]Infectious Department, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
  • [ 18 ] [Wang Q.]Infectious Department, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
  • [ 19 ] [Wang Q.]Infectious Department, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
  • [ 20 ] [Wang Q.]Infectious Department, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
  • [ 21 ] [Lin J.]Infectious Department, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
  • [ 22 ] [Lin J.]Infectious Department, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
  • [ 23 ] [Lin J.]Infectious Department, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
  • [ 24 ] [Lin J.]Infectious Department, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
  • [ 25 ] [Lin J.]Infectious Department, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
  • [ 26 ] [Ao W.]Infectious Department, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
  • [ 27 ] [Ao W.]Infectious Department, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
  • [ 28 ] [Ao W.]Infectious Department, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
  • [ 29 ] [Ao W.]Infectious Department, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
  • [ 30 ] [Ao W.]Infectious Department, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
  • [ 31 ] [Ye H.]Infectious Department, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
  • [ 32 ] [Ye H.]Infectious Department, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
  • [ 33 ] [Ye H.]Infectious Department, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
  • [ 34 ] [Ye H.]Infectious Department, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
  • [ 35 ] [Ye H.]Infectious Department, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
  • [ 36 ] [Han X.]Fuzhou University, College of Biological Science and Engineering, Fuzhou, 350025, China

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Source ：

Cellular and molecular biology (Noisy-le-Grand, France)

ISSN： 1165-158X

Year： 2023

Issue： 4

Volume： 69

Page： 125-132

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WoS CC Cited Count： 0

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