The　HIV　latent　reservoir　is　the　main　obstacle　to　the　eradication　of　AIDS.　Recent　studies　have　shown　that　the　RNA　m6A　is　involved　in　the　regulation　of　HIV-1　replication.　However,　no　relevant　study　has　reported　the　relationship　between　RNA　m6A　and　HIV　latent　reservoir.　For　this　purpose,　peripheral　blood　mononuclear　cell　(PBMC)　was　collected　from　36　HIV-infected　patients　at　1,　24,　and　48　weeks　after　treatment　initiation.　The　number　of　CD4+　and　CD8+　T　cells　was　detected　by　flow　cytometry.　Amount　of　HIV　DNA　in　the　PBMC　samples　one　week　after　treatment　initiation　was　detected　by　Q-PCR.　The　expression　levels　of　23　RNA-m6A-related　genes　were　detected　by　Q-PCR　and　Pearson＇s　correlation　analysis　was　performed.　Results　showed　that　there　was　a　negative　correlation　between　HIV　DNA　concentration　and　the　number　of　CD4+　T　cells　(r=-0.32,　p=0.05;　r=-0.32,　p=0.06)　and　a　positive　correlation　with　the　number　of　CD8+　T　cells　(r=0.48,　p=0.003;　r=0.37,　p=0.03).　Furthermore,　a　negative　correlation　was　observed　between　HIV　DNA　concentration　and　the　CD4+/CD8+　T　cell　ratio　(r=-0.53,　p=0.001;　r=-0.51,　p=0.001).　RNAm6A　related　genes　which　correlated　with　HIV　DNA　concentration　includedALKBH5　(r=-0.45,　p=-0.006),　METTL3　(r=0.73,　p=2.76e-7),　METTL16　(r=0.71,　p=1.21e2.76e-06),　YTHDF1　(r=0.47,　p=0.004).　Moreover,　they　have　different　degrees　of　correlation　with　numbers　ofCD4+　and　CD8+　T　cell　subsets,　and　the　CD4+/CD8+T　cell　ratio.　In　addition,　the　expression　of　RBM15　was　not　correlated　with　HIV　DNA　concentration　but　was　significantly　negatively　correlated　with　the　number　of　CD4+T　cells　(r=-0.40,　p=0.02).　In　conclusion,　the　expression　ofALKBH5,　METTL3,　and　METTL16　is　correlated　with　the　HIV　DNA　level,　the　levels　of　CD4+　and　CD8+　T　cell　counts,　and　the　CD4+/CD8+　T　cell　ratio.　RBM15　is　independent　of　HIV　DNA　level　and　negatively　correlated　with　the　number　of　CD4+T　cells.