In　this　study,　a　comprehensive　approach　was　adopted　by　combining　micro-flotation,　microscopy　(optical　and　scanning　electron　microscopy),　spectroscopy　(X-ray　diffraction　and　X-ray　photoelectron　spectroscopy),　contact　angle,　and　electron　backscatter　diffraction　analysis　techniques.　The　effects　of　differences　in　oxidation　rates　on　the　floatability　and　surface　properties　of　high-sulfur　epithermal　pyrite　(HSEP)　in　a　shallow　ore　belt　and　porphyry　pyrite　(PP)　in　a　deep　ore　belt　of　a　hydrothermal　deposit　were　investigated,　and　the　relationship　between　the　mineralogical　properties　and　oxidation　rate　was　studied.　The　experimental　results　showed　that　the　discrepancy　in　the　oxidation　rate　led　to　distinct　differences　in　the　flotation　performances　of　HSEP　and　PP;　the　former　exhibited　a　higher　oxidation　rate,　and　the　floatability　significantly　decreased,　whereas　the　latter　exhibited　a　lower　oxidation　rate,　and　the　floatability　remained　essentially　unchanged.　This　is　attributed　to　the　difference　in　the　crystal　structures　of　the　two　types　of　pyrite.　In　addition　to　the　various　reaction　sensitivities　of　the　different　crystal　planes,　the　distribution　densities　of　Fe　and　S　atoms　along　the　preferred　orientation　crystal　plane　of　HSEP　were　higher　than　those　of　PP.　This　was　conducive　to　the　formation　of　Fe(III)-S　and　S2-,　thereby　accelerating　the　oxidation　reaction.