Polyethylene　terephthalate　(PET)　is　a　polymer　synthesized　via　the　dehydration　and　condensation　reaction　between　ethylene　glycol　and　terephthalic　acid.　PET　has　emerged　as　one　of　the　most　extensively　employed　plastic　materials　due　to　its　exceptional　plasticity　and　durability.　Nevertheless,　PET　has　a　complex　structure　and　is　extremely　difficult　to　degrade　in　nature,　causing　severe　pollution　to　the　global　ecological　environment　and　posing　a　threat　to　human　health.　Currently,　the　methods　for　PET　processing　mainly　include　physical,　chemical,　and　biological　methods.　Biological　enzyme　degradation　is　considered　the　most　promising　PET　degradation　method.　In　recent　years,　an　increasing　number　of　enzymes　that　can　degrade　PET　have　been　identified,　and　they　primarily　target　the　ester　bond　of　PET.　This　review　comprehensively　introduced　the　latest　research　progress　in　PET　enzymatic　degradation　from　the　aspects　of　PET-degrading　enzymes,　PET　biodegradation　pathways,　the　catalytic　mechanism　of　PET-degrading　enzymes,　and　biotechnological　strategies　for　enhancing　PET-degrading　enzymes.　On　this　basis,　the　current　challenges　within　the　enzymatic　PET　degradation　process　were　summarized,　and　the　directions　that　need　to　be　worked　on　in　the　future　were　pointed　out.　This　review　provides　a　reference　and　basis　for　the　subsequent　effective　research　on　PET　biodegradation.