Neuromodulation　techniques　are　essential　for　exploring　brain　science　and　supporting　treatments　for　neurological　disorders.　Compared　to　electrical　neuromodulation,　optogenetic　neuromodulation　offers　advantages　in　cell　type　specificity　and　spatial　precision.　However,　existing　optogenetic　neuromodulation　systems　have　limited　functionality　(unable　to　simultaneously　possess　functions　including　optogenetic　stimulation,　recording,　and　micro-LED　(micro-Light-Emitting　Diode)　status　monitoring)　and　will　restrict　normal　biological　activities　due　to　their　large　size.　To　this　end,　this　paper　presents　an　optogenetic　neuromodulation　system,　including　a　specified　neuromodulation　IC　(Integrated　Circuit)　and　a　customized　optrode.　The　ASIC　(Application　Specific　Integrated　Circuit)　includes　a　16-channel　neural　signal　recording　module,　a　4-channel　optogenetic　neurostimulator　module,　and　a　4-channel　micro-LED　detection　module.　The　micro-LED　detection　module　monitors　the　micro-LED＇s　long-term　status　in　real　time　and　provides　the　direct　output　of　its　working　status　for　convenient　user　access.　The　neuromodulation　ASIC　was　fabricated　in　the　TSMC　65　nm　process,　and　an　in　situ　normal　saline　experiment　was　conducted　to　test　the　neuromodulation　system＇s　function.