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author：

Xia, Y. (Xia, Y..) [1] | Zheng, R. (Zheng, R..) [2] | Wang, L. (Wang, L..) [3] | Zhang, A. (Zhang, A..) [4] | Li, D. (Li, D..) [5] | Wu, Y. (Wu, Y..) [6] | Gao, Y. (Gao, Y..) [7] | Xu, Y. (Xu, Y..) [8] | Zhang, B. (Zhang, B..) [9] | Li, H. (Li, H..) [10] | Mak, P.U. (Mak, P.U..) [11] | Vai, M.I. (Vai, M.I..) [12] | Pun, S.H. (Pun, S.H..) [13]

Indexed by：

Scopus

Abstract：

Neuromodulation　techniques　are　essential　for　exploring　brain　science　and　supporting　treatments　for　neurological　disorders.　Compared　to　electrical　neuromodulation,　optogenetic　neuromodulation　offers　advantages　in　cell　type　specificity　and　spatial　precision.　However,　existing　optogenetic　neuromodulation　systems　have　limited　functionality　(unable　to　simultaneously　possess　functions　including　optogenetic　stimulation,　recording,　and　micro-LED　(micro-Light-Emitting　Diode)　status　monitoring)　and　will　restrict　normal　biological　activities　due　to　their　large　size.　To　this　end,　this　paper　presents　an　optogenetic　neuromodulation　system,　including　a　specified　neuromodulation　IC　(Integrated　Circuit)　and　a　customized　optrode.　The　ASIC　(Application　Specific　Integrated　Circuit)　includes　a　16-channel　neural　signal　recording　module,　a　4-channel　optogenetic　neurostimulator　module,　and　a　4-channel　micro-LED　detection　module.　The　micro-LED　detection　module　monitors　the　micro-LED’s　long-term　status　in　real　time　and　provides　the　direct　output　of　its　working　status　for　convenient　user　access.　The　neuromodulation　ASIC　was　fabricated　in　the　TSMC　65　nm　process,　and　an　in　situ　normal　saline　experiment　was　conducted　to　test　the　neuromodulation　system’s　function.　©　2023　by　the　authors.

Keyword：

ASIC micro-LED detection neural signal recording neural stimulation optogenetic neuromodulation system

Community：

  • [ 1 ] [Xia Y.]State Key Laboratory of Analog and Mixed-Signal VLSL, University of Macau, Macao
  • [ 2 ] [Xia Y.]Institute of Microelectronics, University of Macau, Macao
  • [ 3 ] [Xia Y.]Joint Laboratory of Zhuhai UM Science and Technology Research Institute, Lingyange Semiconductor Incorporated, Zhuhai, 519031, China
  • [ 4 ] [Xia Y.]Department of Electrical and Computer Engineering, Faculty of Science and Technology, University of Macau, Macao
  • [ 5 ] [Zheng R.]State Key Laboratory of Analog and Mixed-Signal VLSL, University of Macau, Macao
  • [ 6 ] [Zheng R.]Institute of Microelectronics, University of Macau, Macao
  • [ 7 ] [Wang L.]State Key Laboratory of Analog and Mixed-Signal VLSL, University of Macau, Macao
  • [ 8 ] [Wang L.]Institute of Microelectronics, University of Macau, Macao
  • [ 9 ] [Wang L.]Joint Laboratory of Zhuhai UM Science and Technology Research Institute, Lingyange Semiconductor Incorporated, Zhuhai, 519031, China
  • [ 10 ] [Wang L.]Department of Electrical and Computer Engineering, Faculty of Science and Technology, University of Macau, Macao
  • [ 11 ] [Zhang A.]State Key Laboratory of Analog and Mixed-Signal VLSL, University of Macau, Macao
  • [ 12 ] [Zhang A.]Institute of Microelectronics, University of Macau, Macao
  • [ 13 ] [Zhang A.]Joint Laboratory of Zhuhai UM Science and Technology Research Institute, Lingyange Semiconductor Incorporated, Zhuhai, 519031, China
  • [ 14 ] [Zhang A.]Department of Electrical and Computer Engineering, Faculty of Science and Technology, University of Macau, Macao
  • [ 15 ] [Li D.]State Key Laboratory of Analog and Mixed-Signal VLSL, University of Macau, Macao
  • [ 16 ] [Li D.]Institute of Microelectronics, University of Macau, Macao
  • [ 17 ] [Li D.]Joint Laboratory of Zhuhai UM Science and Technology Research Institute, Lingyange Semiconductor Incorporated, Zhuhai, 519031, China
  • [ 18 ] [Li D.]Department of Electrical and Computer Engineering, Faculty of Science and Technology, University of Macau, Macao
  • [ 19 ] [Wu Y.]Department of Electrical and Computer Engineering, Faculty of Science and Technology, University of Macau, Macao
  • [ 20 ] [Gao Y.]College of Physical and Information Engineering, Fuzhou University, Fuzhou, 350108, China
  • [ 21 ] [Xu Y.]School of Electronics and Information Technology, Sun Yat-sen University, Guangzhou, 510006, China
  • [ 22 ] [Zhang B.]School of Electronics and Information Technology, Sun Yat-sen University, Guangzhou, 510006, China
  • [ 23 ] [Li H.]Joint Laboratory of Zhuhai UM Science and Technology Research Institute, Lingyange Semiconductor Incorporated, Zhuhai, 519031, China
  • [ 24 ] [Mak P.U.]Joint Laboratory of Zhuhai UM Science and Technology Research Institute, Lingyange Semiconductor Incorporated, Zhuhai, 519031, China
  • [ 25 ] [Mak P.U.]Department of Electrical and Computer Engineering, Faculty of Science and Technology, University of Macau, Macao
  • [ 26 ] [Vai M.I.]State Key Laboratory of Analog and Mixed-Signal VLSL, University of Macau, Macao
  • [ 27 ] [Vai M.I.]Joint Laboratory of Zhuhai UM Science and Technology Research Institute, Lingyange Semiconductor Incorporated, Zhuhai, 519031, China
  • [ 28 ] [Vai M.I.]Department of Electrical and Computer Engineering, Faculty of Science and Technology, University of Macau, Macao
  • [ 29 ] [Pun S.H.]State Key Laboratory of Analog and Mixed-Signal VLSL, University of Macau, Macao
  • [ 30 ] [Pun S.H.]Institute of Microelectronics, University of Macau, Macao
  • [ 31 ] [Pun S.H.]Joint Laboratory of Zhuhai UM Science and Technology Research Institute, Lingyange Semiconductor Incorporated, Zhuhai, 519031, China
  • [ 32 ] [Pun S.H.]Department of Electrical and Computer Engineering, Faculty of Science and Technology, University of Macau, Macao

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Source ：

Electronics (Switzerland)

ISSN： 2079-9292

Year： 2023

Issue： 23

Volume： 12

1 . 7 6 4

JCR@2018

CAS Journal Grade：3

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ESI Highly Cited Papers on the List： 0 Unfold All

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30 Days PV： 0

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