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author：

Tan, C. (Tan, C..) [1] | Li, X. (Li, X..) [2] | Li, Z. (Li, Z..) [3] | Lu, S. (Lu, S..) [4] | Wang, F. (Wang, F..) [5] | Liu, Y. (Liu, Y..) [6] | Wen, F. (Wen, F..) [7] | Li, R. (Li, R..) [8] | Tu, D. (Tu, D..) [9] | Chen, Z. (Chen, Z..) [10] | Chen, X. (Chen, X..) [11]

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Scopus

Abstract：

The　development　of　near-infrared　(NIR)-responsive　upconversion　nanoplatforms　for　photodynamic　therapy　(PDT)　has　attracted　considerable　attention　in　recent　years,　but　is　still　limited　by　the　low　PDT　efficacy.　Herein,　we　designed　and　synthesized　a　NIR-responsive　nanoplatform　through　the　integration　of　lanthanide-doped　upconversion　nanoparticles　(UCNPs),　Pt-decorated　porphyrin　metal-organic　frameworks　(PMOFs)　and　NIR　dye　IR808　into　a　core-shell　structure　for　highly　efficient　antibacterial　PDT.　The　PMOF　shell　can　function　not　only　as　a　photosensitizer　to　absorb　the　upconversion　luminescence　(UCL)　of　UCNPs　for　singlet　oxygen　(1O2)　generation,　but　also　as　a　porous　host　material　for　loading　of　IR808.　Remarkably,　we　demonstrated　that　the　heavy-atom　effect　of　Pt(II)　can　simultaneously　enhance　the　intersystem　crossing　(S1→T1)　efficiencies　of　the　IR808　and　the　porphyrin　ligand　Pt-TCPP,　resulting　in　the　enhancement　of　dye-triplet-sensitized　UCL　of　UCNPs　and　1O2　production　capacity　of　the　photosensitizer.　As　a　result,　the　proposed　nanoplatform　exhibited　excellent　1O2　production　and　a　significant　bactericidal　activity　against　methicillin-resistant　Staphylococcus　aureus　(MRSA)　with　5.27　log10　(＞　99.999%)　killing　efficacy.　These　findings　will　pave　the　way　for　designing　highly　efficient　PDT　nanoplatforms　and　accelerate　their　biomedical　applications.　©　2023　Elsevier　Ltd

Keyword：

Dye sensitization Heavy-atom effect Photodynamic therapy Porphyrin metal-organic frameworks Upconversion nanoparticles

Community：

  • [ 1 ] [Tan C.]CAS Key Laboratory of Design and Assembly of Functional Nanostructures, Fujian Key Laboratory of Nanomaterials, and State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fujian, Fuzhou, 350002, China
  • [ 2 ] [Tan C.]College of Chemical Engineering, Fuzhou University, Fujian, Fuzhou, 350116, China
  • [ 3 ] [Tan C.]Fujian College, University of Chinese Academy of Sciences, Fujian, Fuzhou, 350116, China
  • [ 4 ] [Li X.]CAS Key Laboratory of Design and Assembly of Functional Nanostructures, Fujian Key Laboratory of Nanomaterials, and State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fujian, Fuzhou, 350002, China
  • [ 5 ] [Li X.]Fujian Science & Technology Innovation Laboratory for Optoelectronic Information of China, Fujian, Fuzhou, 350108, China
  • [ 6 ] [Li X.]Fujian College, University of Chinese Academy of Sciences, Fujian, Fuzhou, 350116, China
  • [ 7 ] [Li Z.]CAS Key Laboratory of Design and Assembly of Functional Nanostructures, Fujian Key Laboratory of Nanomaterials, and State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fujian, Fuzhou, 350002, China
  • [ 8 ] [Li Z.]Fujian College, University of Chinese Academy of Sciences, Fujian, Fuzhou, 350116, China
  • [ 9 ] [Lu S.]CAS Key Laboratory of Design and Assembly of Functional Nanostructures, Fujian Key Laboratory of Nanomaterials, and State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fujian, Fuzhou, 350002, China
  • [ 10 ] [Lu S.]Fujian Science & Technology Innovation Laboratory for Optoelectronic Information of China, Fujian, Fuzhou, 350108, China
  • [ 11 ] [Lu S.]Fujian College, University of Chinese Academy of Sciences, Fujian, Fuzhou, 350116, China
  • [ 12 ] [Wang F.]CAS Key Laboratory of Design and Assembly of Functional Nanostructures, Fujian Key Laboratory of Nanomaterials, and State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fujian, Fuzhou, 350002, China
  • [ 13 ] [Wang F.]Fujian College, University of Chinese Academy of Sciences, Fujian, Fuzhou, 350116, China
  • [ 14 ] [Liu Y.]CAS Key Laboratory of Design and Assembly of Functional Nanostructures, Fujian Key Laboratory of Nanomaterials, and State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fujian, Fuzhou, 350002, China
  • [ 15 ] [Liu Y.]Fujian Science & Technology Innovation Laboratory for Optoelectronic Information of China, Fujian, Fuzhou, 350108, China
  • [ 16 ] [Liu Y.]Fujian College, University of Chinese Academy of Sciences, Fujian, Fuzhou, 350116, China
  • [ 17 ] [Wen F.]CAS Key Laboratory of Design and Assembly of Functional Nanostructures, Fujian Key Laboratory of Nanomaterials, and State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fujian, Fuzhou, 350002, China
  • [ 18 ] [Wen F.]Fujian College, University of Chinese Academy of Sciences, Fujian, Fuzhou, 350116, China
  • [ 19 ] [Li R.]CAS Key Laboratory of Design and Assembly of Functional Nanostructures, Fujian Key Laboratory of Nanomaterials, and State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fujian, Fuzhou, 350002, China
  • [ 20 ] [Li R.]Fujian Science & Technology Innovation Laboratory for Optoelectronic Information of China, Fujian, Fuzhou, 350108, China
  • [ 21 ] [Tu D.]CAS Key Laboratory of Design and Assembly of Functional Nanostructures, Fujian Key Laboratory of Nanomaterials, and State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fujian, Fuzhou, 350002, China
  • [ 22 ] [Tu D.]Fujian Science & Technology Innovation Laboratory for Optoelectronic Information of China, Fujian, Fuzhou, 350108, China
  • [ 23 ] [Tu D.]Fujian College, University of Chinese Academy of Sciences, Fujian, Fuzhou, 350116, China
  • [ 24 ] [Chen Z.]CAS Key Laboratory of Design and Assembly of Functional Nanostructures, Fujian Key Laboratory of Nanomaterials, and State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fujian, Fuzhou, 350002, China
  • [ 25 ] [Chen Z.]Fujian Science & Technology Innovation Laboratory for Optoelectronic Information of China, Fujian, Fuzhou, 350108, China
  • [ 26 ] [Chen Z.]Fujian College, University of Chinese Academy of Sciences, Fujian, Fuzhou, 350116, China
  • [ 27 ] [Chen X.]CAS Key Laboratory of Design and Assembly of Functional Nanostructures, Fujian Key Laboratory of Nanomaterials, and State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fujian, Fuzhou, 350002, China
  • [ 28 ] [Chen X.]Fujian Science & Technology Innovation Laboratory for Optoelectronic Information of China, Fujian, Fuzhou, 350108, China
  • [ 29 ] [Chen X.]College of Chemical Engineering, Fuzhou University, Fujian, Fuzhou, 350116, China
  • [ 30 ] [Chen X.]Fujian College, University of Chinese Academy of Sciences, Fujian, Fuzhou, 350116, China

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Nano Today

ISSN： 1748-0132

Year： 2024

Volume： 54

1 3 . 2 0 0

JCR@2023

Cited Count：

WoS CC Cited Count：

SCOPUS Cited Count： 10

ESI Highly Cited Papers on the List： 0 Unfold All

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Chinese Cited Count：

30 Days PV： 2

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