In　the　present　study,　a　novel　peroxyoxalate　CE-CL　system　was　developed　to　achieve　high　signal　stability　and　sensitivity　based　on　a　design　of　a　new　interface　including　a　new　mixing　mode　and　a　new　grounding　electrode　mode.　Amino　acids　fluorescently　tagged　with　dansyl　chloride　and　naphthalene-2,3-dicarboxaldehyde(NDA)　were　used　for　the　study.　Experiment　results　show　this　new　system　is　quite　effective　to　separate　and　detect　amine　acid　with　high　stability　and　resolute.　The　detection　limits　were　1.1　nmol/L　for　dansyl-leucine　(Leu)　and　2.0　nmol/L　for　dansyl-aspartic　acid　(Asp).　The　relative　standard　deviations　of　peak　height　and　migration　time　were　in　the　ranges　of　2.3-3.8%　and　1.2-1.5%,　respectively.　Copyright　(c)　2008　John　Wiley　&　Sons,　Ltd.