The　treatment　of　emerging　contaminants　is　essential　but　challenging.　Herein,　a　novel　MOF/PAN　fibrous　composite　(TCPP@UiO-66/PAN)　was　synthesized　and　used　as　a　self-cleaning　membrane　for　the　efficient　removal　of　a　typical　emerging　contaminant,　diclofenac　sodium　(DF).　The　introduction　of　the　secondary　linker　tetra(4-carboxyphenyl)porphyrin　(TCPP)　served　to　expand　the　pores　and　enhance　its　photocatalytic　activity.　TCPP@UiO-66/PAN　shows　higher　adsorption　capacity　and　initial　adsorption　rate　than　UiO-66/PAN.　The　maximum　adsorption　capacity　of　DF　on　TCPP@UiO-66/PAN　reached　202　mg/g　by　Langmuir　model.　The　DF　adsorption　mechanism　involves　the　π-π/anion-π　interaction,　Lewis　acid-base　interaction,　and　hydrogen　bonding.　Based　on　the　dynamic　filtration　experiment,　TCPP@UiO-66/PAN　exhibited　a　remarkable　treatment　capacity　for　DF-contaminated　water,　measuring　3.75　×　104　kg/kg.　Given　its　fibrous　membrane　structure,　TCPP@UiO-66/PAN　could　be　easily　separated　from　water　and　reused.　In-situ　photo-regeneration　emerged　as　a　highly　effective　method　for　regenerating　TCPP@UiO-66/PAN　after　reaching　adsorption　saturation,　with　over　95　%　DF　degradation　achieved　under　sunlight　irradiation.　The　decomposition　of　DF　primarily　resulted　from　the　generation　of　h+　and　1O2.　Additionally,　TCPP@UiO-66/PAN　exhibited　notable　antibacterial　properties　when　exposed　to　visible　light.　In　vitro　cytotoxicity　assessments　further　confirmed　the　safety　of　these　MOF/PAN　composites.　Combining　the　advantages　of　hybrid-linker　strategy　and　fibrous　composite,　this　work　provided　new　insight　into　constructing　MOF-based　functional　material　for　wastewater　purification.　©　2024　Elsevier　B.V.