The　practical　application　of　rechargeable　aqueous　zinc-ion　batteries　(ZIBs)　has　been　severely　hindered　by　detrimental　dendrite　growth,　uncontrollable　hydrogen　evolution,　and　unfavorable　side　reactions　occurring　at　the　Zn　metal　anode.　Here,　we　applied　a　Prussian　blue　analogue　(PBA)　material　K2Zn3(Fe(CN)6)2　as　an　artificial　solid　electrolyte　interphase　(SEI),　by　which　the　plentiful　-C≡N-　ligands　at　the　surface　and　the　large　channels　in　the　open　framework　structure　can　operate　as　a　highly　zincophilic　moderator　and　ion　sieve,　inducing　fast　and　uniform　nucleation　and　deposition　of　Zn.　Additionally,　the　dense　interface　effectively　prevents　water　molecules　from　approaching　the　Zn　surface,　thereby　inhibiting　the　hydrogen-evolution-resultant　side　reactions　and　corrosion.　The　highly　reversible　Zn　plating/stripping　is　evidenced　by　an　elevated　Coulombic　efficiency　of　99.87%　over　600　cycles　in　a　Zn/Cu　cell　and　a　prolonged　lifetime　of　860　h　at　5　mA　cm−2,　2　mAh　cm−2　in　a　Zn/Zn　symmetric　cell.　Furthermore,　the　PBA-coated　Zn　anode　ensures　the　excellent　rate　and　cycling　performance　of　an　α-MnO2/Zn　full　cell.　This　work　provides　a　simple　and　effective　solution　for　the　improvement　of　the　Zn　anode,　advancing　the　commercialization　of　aqueous　ZIBs.　©　2024　by　the　authors.