Implantations　of　scaffold　materials　for　bone　lesion　rectification　involves　multifaceted　cascade　reaction　process,　principally　encompassing　an　initial　inflammatory　response　followed　by　subsequent　osteogenic　restoration.　The　optimal　bone　scaffolds　should　possess　not　solely　robust　osteogenic　potential,　but　also　the　control　of　the　host＇s　immune　response　towards　the　scaffolds.　The　development　of　bone　repair　scaffold　materials　boasting　intelligent　anti-inflammatory　capabilities　is　of　paramount　importance.　Herein,　we　constructed　a　novel　3D-printed　drug　delivery　Hydroxyapatite+　κ-Carrageenan/Polyvinyl　alcohol　composite　scaffold　(HA+　κ-CA/PVA)　incorporating　mesoporous　hydroxyapatite　(MHA)　loaded　with　icariin　(ICA),　for　enhancing　anti-inflammation　and　bone　repair.　Above　all,　the　scaffolds　with　superior　printability　were　developed　by　altering　the　proportion　of　polyvinyl　alcohol　(PVA)　and　κ-carrageenan　(κ-CA).　The　HCP　(HA+　κ-CA/PVA)　scaffolds　with　the　optimal　organic　compound　ratio　possessed　a　highly　stable　structure,　characterized　by　excellent　interconnected　channels.　Notably,　the　HCP　scaffolds　with　1:1–12%　(1:1　represents　the　solid　content　ratio　of　κ-CA　and　PVA,　and　12%　means　the　mass　fraction　of　PVA　aqueous　solution)　exhibited　marvelous　hydrophilicity,　swelling,　mineralization　in　vitro　and　optimal　mechanical　properties.　Furthermore,　the　drug　ICA　loaded　with　MHA　was　further　incorporated　to　achieve　the　sustained　release　of　the　drug　within　the　scaffolds.　In　vitro　cell　experiments　verified　that　the　ICA-laden　scaffolds　considerably　stimulated　the　differentiation　of　osteoblasts　MC3TC-E1　and　regulated　the　polarization　of　macrophages　RAW264.7　to　M2　type.　These　findings　suggest　that　3D　fabricated　HCP　scaffolds　laden　with　ICA　hold　immense　potential　in　bone　tissue　regeneration.　©　2024　Elsevier　Ltd