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author:

Xu, M. (Xu, M..) [1] | Yu, Z. (Yu, Z..) [2] | Wei, Q. (Wei, Q..) [3] (Scholars:魏巧华) | Tang, D. (Tang, D..) [4] (Scholars:唐点平)

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Abstract:

Background: Measurement of endogenous cellular hydrogen peroxide (H2O2) can provide information on cellular status, and help to understand cellular metabolism and signaling processes, thus contributing to elucidation of disease mechanisms and new diagnostics/therapeutic approaches. Results: In this work, Pt–Cd bimetallic nanozyme was successfully prepared via the solvothermal synthetic method for sensitive detection of H2O2. The synthesized Pt–Cd bimetallic nanozyme could exhibited good electrochemical activity. Then, the materials were analyzed for the electrochemical properties and catalytic properties of H2O2 by cyclic voltammetry and chronoamperometry, respectively. Results indicated that the synthesized nanozyme had superior sensitivity (295 μA⸳mM−1⸳cm−2) and selectivity toward H2O2 with a detection limit of 0.21 μM. Further, the Pt–Cd bimetallic nanozyme displayed good electrochemical properties compared to platinum catalysts alone. The application was extended to determine the produced H2O2 from human hepatocellular carcinoma cells (HepG2) and normal hepatocyte (LO2) samples after ascorbic acid stimulation, thus enabling the early warning of cellular carcinogenesis. Significance: This strategy promises simple, rapid, inexpensive and effective electrochemical sensing and provides a new pathway for the synthesis of bimetallic nanozymes to construct an electrochemical sensor for the sensitive detection of H2O2. © 2024 Elsevier B.V.

Keyword:

Enzyme-free electrochemical sensor Hepatocellular carcinoma cells Intracellularly-originated hydrogen peroxide Pt–Cd bimetallic nanozyme

Community:

  • [ 1 ] [Xu M.]Key Laboratory for Analytical Science of Food Safety and Biology (MOE & Fujian Province), Department of Chemistry, Fuzhou University, Fuzhou, 350108, China
  • [ 2 ] [Yu Z.]Key Laboratory for Analytical Science of Food Safety and Biology (MOE & Fujian Province), Department of Chemistry, Fuzhou University, Fuzhou, 350108, China
  • [ 3 ] [Wei Q.]Key Laboratory for Analytical Science of Food Safety and Biology (MOE & Fujian Province), Department of Chemistry, Fuzhou University, Fuzhou, 350108, China
  • [ 4 ] [Tang D.]Key Laboratory for Analytical Science of Food Safety and Biology (MOE & Fujian Province), Department of Chemistry, Fuzhou University, Fuzhou, 350108, China

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Source :

Analytica Chimica Acta

ISSN: 0003-2670

Year: 2024

Volume: 1324

5 . 7 0 0

JCR@2023

CAS Journal Grade:2

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WoS CC Cited Count:

SCOPUS Cited Count:

ESI Highly Cited Papers on the List: 0 Unfold All

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Chinese Cited Count:

30 Days PV: 0

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