Background:　The　prognosis　of　patients　with　hepatoblastoma　has　been　unsatisfactory.　This　study　analyzed　the　effects　of　different　treatment　methods　on　cancer-specific　survival　(CSS)　in　children　with　hepatoblastoma.　Method:　From　2000　to　2018,　patients　with　hepatoblastoma　were　included　in　the　Surveillance,　Epidemiology,　and　End　Results　(SEER)　database.　CSS　was　estimated　using　the　Kaplan-Meier　method.　Cox　regression　analysis　assessed　prognostic　factors.　The　predictive　models　were　validated　using　the　concordance　index　(C-index),　calibration　curve　and　receiver　operating　characteristic　(ROC)　curve.　Result:　Of　the　785　included　patients,　730　(93.0　%)　underwent　chemotherapy,　516　(65.7　%)　underwent　liver　tumour　resection　and　129　(16.4　%)　underwent　liver　transplantation.　Both　chemotherapy　and　surgery　could　significantly　improve　the　CSS　rate　(all　p　＜　0.001).　However,　there　was　no　difference　in　CSS　rate　between　the　two　surgical　methods　(liver　tumour　resection　and　liver　transplantation)　(p　=　0.613).　Further　subgroup　analysis　revealed　that　children　who　underwent　liver　tumour　resection　or　liver　transplantation　based　on　chemotherapy　(all　p　＞　0.05)　had　a　similar　prognosis.　Multivariate　analysis　revealed　that　age　(p　=　0.003),　race　(p　=　0.001),　operative　method　(p　＜　0.001),　chemotherapy　(p　＜　0.001),　distant　metastasis　(p　＜　0.001)　and　tumour　size　(p　＜　0.001)　were　independent　factors　related　to　CSS.　The　C-index　of　the　new　nomogram　was　0.759,　and　its　consistency　was　good.　The　ROC　curves　verified　that　the　nomogram　had　a　better　prediction　ability　for　1-,　3-　and　5-year　CSS　rates.　Conclusion:　In　children　with　hepatoblastoma,　there　was　no　statistically　significant　difference　in　CSS　between　chemotherapy　combined　with　liver　transplantation　and　liver　tumour　resection.　The　nomogram　we　constructed　demonstrated　satisfactory　CSS　prediction　ability.