The　combination　therapy　of　magnetic　hyperthermia　and　thermosensitive　liposomes　(TSL)　is　an　emerging　and　effective　cancer　treatment　method.　The　heat　generation　of　magnetic　nanoparticles　(MNPs)　due　to　an　external　alternating　magnetic　field　can　not　only　directly　damage　tumor　cells,　but　also　serves　as　a　triggering　factor　for　the　release　of　doxorubicin　from　TSL.　The　aim　of　this　study　is　to　investigate　the　effects　in　the　degree　of　tumor　cell　damage　of　two　proposed　injection　strategies　that　consider　intravenous　administration.　Since　both　MNPs　and　TSL　enter　the　tumor　region　intravenously,　this　study　establishes　a　biological　geometric　model　based　on　an　experiment-based　vascular　distribution.　Furthermore,　this　study　derives　the　flow　velocity　of　interstitial　fluid　after　coupling　the　pressure　distribution　inside　blood　vessels　and　the　pressure　distribution　of　interstitial　fluid,　which　then　provides　the　convective　velocity　for　the　calculation　of　subsequent　nanoparticle　concentration.　Different　injection　strategies　for　the　proposed　approach　are　evaluated　by　drug　delivery　result,　temperature　distribution,　and　tumor　cell　damage.　Simulation　results　demonstrate　that　the　proposed　delayed　injection　strategy　after　optimization　can　not　only　result　in　a　wider　distribution　for　MNPs　and　TSL　due　to　the　sufficient　diffusion　time,　but　also　improves　the　distribution　of　the　temperature　and　drug　concentration　fields　for　the　overall　efficacy　of　combination　therapy.