Among　individuals　who　wear　removable　dentures,　there　is　a　significant　likelihood,　reaching　up　to　70　%,　of　experiencing　a　condition　known　as　denture-induced　stomatitis.　To　address　this　issue,　a　commonly　used　method　involves　soaking　dentures　in　denture　cleansers　to　eliminate　microorganisms.　However,　the　prolonged　use　of　this　cleaning　method　has　resulted　in　the　emergence　of　drug　resistance.　Composite　antibacterial　nanomaterials　possess　excellent　chemical,　physical,　and　antibacterial　properties,　not　only　allowing　the　individual　components　to　function　but　sometimes　also　leading　to　synergistic　effects　that　enhance　antibacterial　performance.　In　this　study,　we　have　successfully　synthesized　a　new　benzpyrole　derivant/iodocuprate　bio-nanomaterial,　(TMBI)2(Cu2I4)　(TMBI　=　1,1,2,3-Tetramethyl-1H-benzo[e]indolium　cation),　that　demonstrates　remarkable　resistance　to　Candida　albicans,　Streptococcus　mutans,　and　dental　plaque　biofilm.　It　can　effectively　clean　the　surfaces　of　denture　bases　by　removing　Candida　albicans,　Streptococcus　mutans,　and　dental　plaque　biofilm.　Prolonged　immersion　in　this　material　does　not　significantly　affect　the　common　mechanical　properties　of　polymethyl　methacrylate　(PMMA)　denture　bases.　At　effective　antibacterial　concentrations,　this　nanomaterial　(TMBI)2(Cu2I4)　demonstrates　no　residual　cytotoxicity　on　PMMA　denture　bases　after　immersion　and　maintains　excellent　hemocompatibility.　These　findings　indicate　that　(TMBI)2(Cu2I4)　has　the　potential　to　be　a　promising　denture　cleanser.　©　2025　Elsevier　Inc.