The　microenvironment　of　diabetic　wounds　is　exceptionally　complex,　characterized　notably　by　persistent　bacterial　infections　and　the　excessive　production　of　reactive　oxygen　species　(ROS).　Traditional　treatment　methods　often　fall　short　of　achieving　ideal　results.　Consequently,　there　is　an　urgent　need　to　develop　and　implement　more　advanced　and　efficient　treatment　strategies　to　effectively　address　the　complexity　and　recalcitrance　of　diabetic　wounds.　This　study　pioneers　a　novel　approach　by　fabricating　a　silk　fibroin-based　nonwoven　dressing　(SF-Ag-HCA)　under　neutral　conditions,　integrating　silver　ions　with　dihydrocaffeic　acid-modified　silk　fibroin.　Uniquely,　this　dressing　achieves　dual　functionality:　exceptional　antibacterial　efficacy　against　common　pathogens　(E.　coli,　S.　aureus,　P.　aeruginosa)　and　robust　ROS-scavenging　capabilities,　effectively　mitigating　oxidative　stress　and　promoting　immune　homeostasis.　The　SF-Ag-HCA　dressing　not　only　surpasses　conventional　materials　in　regulating　the　wound　microenvironment　but　also　accelerates　re-epithelialization　and　collagen　deposition.　Animal　studies　further　validate　its　superior　performance　in　healing　diabetic　and　infected　wounds　compared　to　commercial　alternatives.　This　innovative　dressing　represents　a　significant　advancement　in　wound　care,　offering　an　integrated,　cost-effective　solution　tailored　for　complex　chronic　wound　management.　©　2025　Wiley-VCH　GmbH.